Immunohistochemical and selected genetic reflex testing of all uterine leiomyosarcomas and STUMPs for ALK gene rearrangement may provide an effective screening tool in identifying uterine ALK-rearranged mesenchymal tumors
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DOI: 10.1007/s00428-018-2428-8
Abstract: We examined the value of targeted molecular screening for the identification of uterine anaplastic lymphoma kinase (ALK)-rearranged mesenchymal tumors, including ALK immunohistochemistry followed by molecular genetic testing, in all uterine leiomyosarcomas and STUMPs (smooth muscle… read more here.
Keywords: rearranged mesenchymal; alk; mesenchymal tumors; uterine leiomyosarcomas ... See more keywords
Role of Homologous Recombination Repair (HRR) Genes in Uterine Leiomyosarcomas: A Retrospective Analysis
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DOI: 10.3390/cancers14081934
Abstract: Simple Summary A more in-depth molecular characterization of uterine leiomyosarcomas (uLMS), a rare disease characterized with dismal prognosis, could provide data suitable for the identification of potential target-based drugs. We aimed to define frequencies of… read more here.
Keywords: uterine leiomyosarcomas; gene alterations; analysis; gene ... See more keywords