Machine learning approach to integrated endometrial transcriptomic datasets reveals biomarkers predicting uterine receptivity in cattle at seven days after estrous
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-72988-3
Abstract: The main goal was to apply machine learning (ML) methods on integrated multi-transcriptomic data, to identify endometrial genes capable of predicting uterine receptivity according to their expression patterns in the cow. Public data from five… read more here.
Keywords: machine; machine learning; learning approach; uterine receptivity ... See more keywords
The effect of repeated light-dark shifts on uterine receptivity and early gestation in mice undergoing embryo transfer
Sign Up to like & getrecommendations! Published in 2018 at "Systems Biology in Reproductive Medicine"
DOI: 10.1080/19396368.2017.1408715
Abstract: ABSTRACT Female shift workers are at increased risk for negative reproductive outcomes, and animal evidence suggests that manipulation of the light-dark cycle is detrimental to early gestation in female mice. Specifically, failure of implantation may… read more here.
Keywords: embryo transfer; early gestation; light dark; uterine receptivity ... See more keywords
Uterine epithelial progesterone receptor governs uterine receptivity through epithelial cell differentiation.
Sign Up to like & getrecommendations! Published in 2020 at "Endocrinology"
DOI: 10.1210/endocr/bqaa195
Abstract: Progesterone receptor (PGR) is indispensable for pregnancy in mammals. Uterine PGR responds to the heightened levels of ovarian progesterone (P4) after ovulation and regulates uterine gene transcription for successful embryo implantation. Although epithelial and stromal… read more here.
Keywords: pgr; uterine receptivity; mice; pgrfl flltfcre ... See more keywords
AMPK is required for uterine receptivity and normal responses to steroid hormones.
Sign Up to like & getrecommendations! Published in 2020 at "Reproduction"
DOI: 10.1530/rep-19-0402
Abstract: We previously demonstrated that 5'-adenosine monophosphate-activated protein kinase (AMPK) is essential for normal reproductive functions in female mice. Conditional ablation of Prkaa1 and Prkaa2, genes that encode the α1 and α2 catalytic domains of AMPK,… read more here.
Keywords: decidualization; mice; prkaa1; cell ... See more keywords
Consistency and Synchronization of AMPK-Glycogen in Endometrial Epithelial Cells is Critical to the Embryo Implantation.
Sign Up to like & getrecommendations! Published in 2022 at "Reproduction"
DOI: 10.1530/rep-21-0382
Abstract: Uterine receptivity to the embryo is crucial for successful implantation. The establishment of uterine receptivity requires a large amount of energy, and abnormal energy regulation causes implantation failure. Glucose metabolism in the endometrium is tissue… read more here.
Keywords: energy; uterine receptivity; implantation; regulation ... See more keywords
Identification of Gene Expression Changes Associated With Uterine Receptivity in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2019.00125
Abstract: The mouse is a widely used animal model for studying human reproduction. Although global gene expression changes associated with human uterine receptivity have been determined by independent groups, the same studies in the mouse are… read more here.
Keywords: receptivity; gene expression; expression changes; receptive uterus ... See more keywords