NTRK and other recently described kinase fusion positive uterine sarcomas: A review of a group of rare neoplasms
Sign Up to like & getrecommendations! Published in 2020 at "Genes"
DOI: 10.1002/gcc.22910
Abstract: The landscape of uterine sarcomas has greatly expanded in recent years to include neoplasms with recurrent gene fusions, such as BCOR and YWHAE translocated high‐grade endometrial stromal sarcomas. Sophisticated molecular techniques have also resulted in… read more here.
Keywords: sarcomas; rare neoplasms; recently described; ntrk recently ... See more keywords
MR Imaging of uterine sarcomas: a comprehensive review with radiologic-pathologic correlation
Sign Up to like & getrecommendations! Published in 2021 at "Abdominal Radiology"
DOI: 10.1007/s00261-021-03263-w
Abstract: The aim of this article is to summarize the MRI features of each sarcoma subtype and to correlate them with its pathological findings. Literature review through PubMed/Medline database to identify relevant articles on uterine sarcomas,… read more here.
Keywords: imaging uterine; review; mri; uterine sarcomas ... See more keywords
Uterine morcellation and survival in uterine sarcomas.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of cancer"
DOI: 10.1016/j.ejca.2018.06.007
Abstract: BACKGROUND There is concern but no solid evidence that morcellation during laparoscopic or vaginal hysterectomy may cause abdominal spread and thereby impaired prognosis of incidental uterine sarcomas. OBJECTIVE Our purpose was to compare survival among… read more here.
Keywords: morcellated group; morcellation; uterine sarcoma; uterine sarcomas ... See more keywords
80 Smarca4 inactivation defines a subset of undifferentiated uterine sarcomas with rhabdoid and small cell features and germline mutation association
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2019-igcs.80
Abstract: Objectives A rare subset of aggressive SMARCA4-deficient uterine sarcomas (SMARCA4-DUS) has been recently proposed, with only a limited number of cases having been previously described. Since potential targeted therapies exist for SMARCA4-defficient tumors, we sought… read more here.
Keywords: smarca4 dus; small cell; uterine sarcomas; smarca4 ... See more keywords
Pegylated liposomal doxorubicin combined with trabectedin as a treatment option in uterine sarcomas: a single-institution retrospective analysis
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2023-005170
Abstract: Objective The use of conventional doxorubicin in combination with trabectedin leads to a considerable prolongation of progression-free survival in the treatment of uterine sarcomas but is associated with dose-limiting toxicities. Significant progression-free survival improvement was… read more here.
Keywords: treatment; uterine sarcomas; pegylated liposomal; liposomal doxorubicin ... See more keywords
Abstract 1766: CREBBP, NOTCH2 and GNASmutational profile in uterine sarcomas
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-1766
Abstract: Background: Uterine sarcomas (US) present clinical challenges due to their dynamic behavior and limited treatment options. Representing 1-3% of uterine cancer cases, these tumors exhibit rapid growth, high recurrence rates, and resistance to the standard… read more here.
Keywords: substitution; crebbp; uterine sarcomas; mutation ... See more keywords
Investigating the diagnostic value of quantitative parameters based on T2-weighted and contrast-enhanced MRI with psoas muscle and outer myometrium as internal references for differentiating uterine sarcomas from leiomyomas at 3T MRI
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Imaging"
DOI: 10.1186/s40644-019-0206-8
Abstract: BackgroundPost-hysterectomy histopathological examination is currently the main diagnostic tool for differentiating uterine sarcomas from leiomyomas. This study aimed to investigate the diagnostic accuracy of preoperative quantitative metrics based on T2-weighted sequences and contrast-enhanced MRI (CE-MRI)… read more here.
Keywords: contrast enhanced; sarcomas leiomyomas; contrast; uterine sarcomas ... See more keywords
Complete remission of patients with heavily pretreated uterine sarcomas by weekly bevacizumab and temozolomide.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.11051
Abstract: 11051 Background: Uterine sarcomas are associated with poor prognosis snce the complete remission is extreme rare. Therefore, treatment with chemotherapy including eribulin or trabectedin, hormone therapy or molecular-targeted therapy including pazopanib or olaratumab was expectd,… read more here.
Keywords: uterine sarcomas; response; complete remission; heavily pretreated ... See more keywords
The role of postoperative radiotherapy in patients with uterine sarcomas: A PSM-IPTW analysis based on SEER database
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Surgery"
DOI: 10.3389/fsurg.2022.985654
Abstract: Objective The optimal adjuvant therapy for uterine sarcomas remains poorly determined due to its rarity and histological diversity. The purpose of the study is to explore and characterize the association between utilization of radiotherapy and… read more here.
Keywords: uterine sarcomas; radiotherapy; seer database; psm iptw ... See more keywords
Isobolographic Analysis Demonstrates the Additive and Synergistic Effects of Gemcitabine Combined with Fucoidan in Uterine Sarcomas and Carcinosarcoma Cells
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DOI: 10.3390/cancers12010107
Abstract: Background: Uterine sarcomas and carcinosarcoma are associated with unfavorable prognosis. The regimens that are used in chemotherapy are associated with high incidence of side effects and usually do not significantly increase patients’ survival rates. In… read more here.
Keywords: sarcomas carcinosarcoma; gemcitabine; carcinosarcoma; fucoidan ... See more keywords
New Insights into Hormonal Therapies in Uterine Sarcomas
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DOI: 10.3390/cancers14040921
Abstract: Simple Summary Uterine sarcomas are rare mesenchymal malignant cancers, and surgery represents the mainstay of treatment for early-stage disease. In metastatic setting, uterine sarcomas’ treatment includes palliative surgery, a metastases resection, chemotherapy and targeted therapy.… read more here.
Keywords: uterine sarcomas; hormonal therapies; role; treatment ... See more keywords