Effects of uteroplacental insufficiency on cardiac development in growth-restricted newborn rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Developmental Origins of Health and Disease"
DOI: 10.1017/s2040174422000575
Abstract: Abstract Fetal growth restriction (FGR) is associated with reduced cardiac function in neonates. Uteroplacental insufficiency (UPI) is the most common cause of FGR. The mechanisms underlying these alterations remain unknown. We hypothesized that UPI would… read more here.
Keywords: growth; uteroplacental insufficiency; cardiac development; restricted newborn ... See more keywords
Uteroplacental insufficiency in rats induces renal apoptosis and delays nephrogenesis completion
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DOI: 10.1111/apha.12982
Abstract: Uteroplacental insufficiency in rats reduces nephron endowment, leptin concentrations and programmes cardiorenal disease in offspring. Cross‐fostering growth‐restricted (Restricted) offspring onto a mother with normal lactation restores leptin concentrations and nephron endowment. This study aimed to… read more here.
Keywords: nephron endowment; restricted offspring; apoptosis; insufficiency rats ... See more keywords
The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life
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DOI: 10.1371/journal.pone.0198490
Abstract: Early life events are associated with the susceptibility to chronic diseases in adult life. Perturbations of endoplasmic reticulum (ER) homeostasis activate the unfolded protein response (UPR), which contributes to the development of metabolic alterations. Our… read more here.
Keywords: unfolded protein; protein response; uteroplacental insufficiency; insufficiency associated ... See more keywords
Pravastatin and placental insufficiency associated disorders: A systematic review and meta-analysis
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DOI: 10.3389/fphar.2022.1021548
Abstract: Background: Uteroplacental insufficiency associated disorders, such as preeclampsia, fetal growth restriction and obstetrical antiphospholipid syndrome, share pathophysiology and risk factors with cardiovascular diseases treated with statins. Objective: To evaluate pregnancy outcomes among women with uteroplacental… read more here.
Keywords: pravastatin; insufficiency associated; associated disorders; uteroplacental insufficiency ... See more keywords
Uteroplacental Insufficiency Causes Microbiota Disruption and Lung Development Impairment in Growth-Restricted Newborn Rats
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DOI: 10.3390/nu14204388
Abstract: Preclinical studies have demonstrated that intrauterine growth retardation (IUGR) is associated with reduced lung development during the neonatal period and infancy. Uteroplacental insufficiency (UPI), affecting approximately 10% of human pregnancies, is the most common cause… read more here.
Keywords: lung development; growth; uteroplacental insufficiency; lung ... See more keywords