Antisense Oligonucleotide Targeting of 3'-UTR of mRNA for Expression Knockdown.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8651-4_6
Abstract: With the recent conditional approval of an antisense oligonucleotide (AON) that restores the reading frame of DMD transcript in a subset of Duchenne muscular dystrophy patients, it has been established that AONs sharing similar chemistry… read more here.
Keywords: targeting utr; utr mrna; oligonucleotide targeting; expression ... See more keywords
Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them
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DOI: 10.1038/nrm.2017.103
Abstract: RNA molecules can fold into intricate shapes that can provide an additional layer of control of gene expression beyond that of their sequence. In this Review, we discuss the current mechanistic understanding of structures in… read more here.
Keywords: mrna structures; structures eukaryotic; rna; functional utr ... See more keywords
CRISPR-Mediated Knockout of Long 3′ UTR mRNA Isoforms in mESC-Derived Neurons
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.789434
Abstract: Alternative cleavage and polyadenylation (APA) is pervasive, occurring for more than 70% of human and mouse genes. Distal poly(A) site selection to generate longer 3′ UTR mRNA isoforms is prevalent in the nervous system, affecting… read more here.
Keywords: mrna isoforms; derived neurons; mesc derived; utr mrna ... See more keywords