NFKBIZ3′ UTR Mutations Confer Selective Growth Advantage and Activate Genes with Therapeutic Implications in Diffuse Large B-Cell Lymphoma
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DOI: 10.1182/blood-2019-127421
Abstract: Introduction: The activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) is characterized by activation of NF-κB signaling and increased mortality. Recurrent mutations affecting genes such as MYD88, CD79A/B and TNFAIP3 have been shown… read more here.
Keywords: dlbcl; growth; mutant lines; cell ... See more keywords
miRNA Mediated Noise Making of 3′UTR Mutations in Cancer
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DOI: 10.3390/genes9110545
Abstract: Somatic mutations in 3′-untranslated regions (3′UTR) do not alter amino acids and are considered to be silent in cancers. We found that such mutations can promote tumor progression by altering microRNA (miRNA) targeting efficiency and… read more here.
Keywords: mirna; utr mutations; somatic mutations; cancer ... See more keywords