Integrative assessment of CIP2A overexpression and mutational effects in human malignancies identifies possible deleterious variants.
Sign Up to like & getrecommendations! Published in 2021 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2021.104986
Abstract: KIAA1524 is the gene encoding the human cancerous inhibitor of PP2A (CIP2A) protein which is regarded as a novel target for cancer therapy. It is overexpressed in 65%-90% of tissues in almost all studied human… read more here.
Keywords: cip2a overexpression; analysis; cip2a; utr variants ... See more keywords
PRKCE non-coding variants influence on transcription as well as translation of its gene
Sign Up to like & getrecommendations! Published in 2022 at "RNA Biology"
DOI: 10.1080/15476286.2022.2139110
Abstract: ABSTRACT Untranslated regions of the gene play a crucial role in gene expression regulation at mRNA and protein levels. Mutations at UTRs impact expression by altering transcription factor binding, transcriptional/translational efficacy, miRNA-mediated gene regulation, mRNA… read more here.
Keywords: transcription; influence; prkce; gene ... See more keywords
Common and Rare 5′UTR Variants Altering Upstream Open Reading Frames in Cardiovascular Genomics
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.841032
Abstract: High-throughput sequencing (HTS) technologies are revolutionizing the research and molecular diagnosis landscape by allowing the exploration of millions of nucleotide sequences at an unprecedented scale. These technologies are of particular interest in the identification of… read more here.
Keywords: reading frames; common rare; upstream open; utr variants ... See more keywords