UVB-mediated DNA damage induces matrix metalloproteinases to promote photoaging in an AhR- and SP1-dependent manner
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DOI: 10.1172/jci.insight.156344
Abstract: It is currently thought that UVB radiation drives photoaging of the skin primarily by generating ROS. In this model, ROS purportedly activates activator protein-1 to upregulate MMPs 1, 3, and 9, which then degrade collagen… read more here.
Keywords: mediated dna; sp1; damage; dna damage ... See more keywords
Kaempferide Prevents Photoaging of Ultraviolet-B Irradiated NIH-3T3 Cells and Mouse Skin via Regulating the Reactive Oxygen Species-Mediated Signalings
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DOI: 10.3390/antiox12010011
Abstract: Kaempferide (KFD) is a naturally occurring flavonoid that exists in various medicinal plants. The pharmaceutical properties of KFD, including its anti-cancer, antioxidant and anti-diabetic effects, have been noted, but the effects of KFD on photoaging… read more here.
Keywords: reactive oxygen; nih 3t3; oxygen species; uvb mediated ... See more keywords