Sociodemographic, Medical, and Psychosocial Factors Associated With Supportive Care Needs in Adults Diagnosed With Uveal Melanoma
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DOI: 10.1001/jamaophthalmol.2018.0019
Abstract: Importance Understanding supportive care needs in patients with cancer is important for developing approaches that enhance quality of life and promote satisfaction with care. Objective To characterize the nature and frequency of sociodemographic, medical, and… read more here.
Keywords: sociodemographic medical; unmet need; ophthalmology; uveal melanoma ... See more keywords
Intraocular Metastasis in Unilateral Multifocal Uveal Melanoma Without Melanocytosis or Germline BAP1 Mutations.
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DOI: 10.1001/jamaophthalmol.2019.3941
Abstract: Importance There has been speculation on the pathogenesis of unilateral multifocal uveal melanoma, but there remains no convincing explanation. Genetic analysis suggests that unilateral multifocal uveal melanoma may represent intraocular metastasis with increased risk of… read more here.
Keywords: melanoma; unilateral multifocal; uveal melanoma; multifocal uveal ... See more keywords
Visual Outcome at 4 Years Following Plaque Radiotherapy and Prophylactic Intravitreal Bevacizumab (Every 4 Months for 2 Years) for Uveal Melanoma: Comparison With Nonrandomized Historical Control Individuals.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2019.5132
Abstract: Importance Radiation retinopathy following plaque radiotherapy for uveal melanoma can lead to vision loss that might be avoided with prophylactic anti-vascular endothelial growth factor treatment. Objective To determine visual outcome following prophylactic intravitreal bevacizumab in… read more here.
Keywords: prophylactic intravitreal; bevacizumab; uveal melanoma; intravitreal bevacizumab ... See more keywords
Evaluation of Racial, Ethnic, and Socioeconomic Associations With Treatment and Survival in Uveal Melanoma, 2004-2014.
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DOI: 10.1001/jamaophthalmol.2020.2254
Abstract: Importance Identifying disparities in uveal melanoma (UM) treatment patterns and survival across racial, ethnic, and socioeconomic (SES) groups reveals possible inequities in ophthalmologic health care. Objective To examine the association of race, ethnicity, and SES… read more here.
Keywords: ethnic socioeconomic; treatment; uveal melanoma; 2004 2014 ... See more keywords
Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence.
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DOI: 10.1002/1878-0261.13128
Abstract: Uveal melanoma (UM) is the most common intraocular tumor in adults. Recurrent mutations in BRCA1-associated protein 1 (BAP1) and splicing factor 3B subunit 1 (SF3B1) display a mutually exclusive pattern in UM, but the underlying… read more here.
Keywords: melanoma; sf3b1; bap1; senescence ... See more keywords
Evaluation of the modified immune prognostic index to prognosticate outcomes in metastatic uveal melanoma patients treated with immune checkpoint inhibitors
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DOI: 10.1002/cam4.3784
Abstract: Metastatic uveal melanoma (MUM) is associated with poor survival and inferior response to immune checkpoint inhibitor (ICI) therapy when compared with metastatic cutaneous melanoma. Currently, prognostic biomarkers are lacking to guide treatment decisions. read more here.
Keywords: uveal melanoma; immune checkpoint; evaluation modified; metastatic uveal ... See more keywords
Sex‐based differences in early and late uveal melanoma‐related mortality
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DOI: 10.1002/cam4.5458
Abstract: It is debated if there are sex‐based differences in survival for patients with uveal melanoma. Previous observations of higher mortality for men in studies with read more here.
Keywords: based differences; sex based; differences early; mortality ... See more keywords
Obstacles to improving outcomes in the treatment of uveal melanoma
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DOI: 10.1002/cncr.31284
Abstract: The rate of advances in uveal melanoma has not kept pace with the rate of advances in cutaneous melanoma. Many patients lack access to or knowledge of specialty centers, and integrated multidisciplinary care between ophthalmology,… read more here.
Keywords: obstacles improving; outcomes treatment; uveal melanoma; improving outcomes ... See more keywords
Germline large deletion of BAP1 and decreased expression in non‐tumor choroid in uveal melanoma patients with high risk for inherited cancer
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DOI: 10.1002/gcc.22752
Abstract: Uveal melanoma (UM) is the most common phenotype in patients with germline BAP1 mutation. This study aimed to identify selection criteria for BAP1 germline testing and assessed the role of large deletion/duplication and epigenetic inactivation.… read more here.
Keywords: bap1; large deletion; uveal melanoma; deletion ... See more keywords
Identification of differentially expressed genes and functional annotations associated with metastases of the uveal melanoma
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DOI: 10.1002/jcb.29250
Abstract: Uveal melanoma (UVM) is an adult intraocular malignancy which is the most frequent and has a high tendency for metastasis. This study aims to develop significant differential gene subnetwork between primary and metastatic UVM to… read more here.
Keywords: functional annotations; metastatic uvm; uveal melanoma; primary metastatic ... See more keywords
Ras–ERK1/2 signaling promotes the development of uveal melanoma by downregulating H3K14ac
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DOI: 10.1002/jcp.28259
Abstract: Ras–extracellular signal‐regulated protein kinases 1 and 2 (ERK1/2) signaling has been proposed as the crucial regulators in the development of various cancers. Histone acetylation at H3 lysine 14 (H3K14ac) is closely associated with gene expression… read more here.
Keywords: uveal melanoma; expression; cell; ras erk1 ... See more keywords