Successive Uveal Melanomas with Different Gene Expression Profiles in an Eye with Ocular Melanocytosis
Sign Up to like & getrecommendations! Published in 2018 at "Ocular Oncology and Pathology"
DOI: 10.1159/000484937
Abstract: Ocular melanocytosis portends a higher risk of uveal melanoma. Multifocal uveal melanoma has been described previously and has been associated with ocular melanocytosis. Historically, histopathology has been used to differentiate tumors; however, molecular profiling now… read more here.
Keywords: risk; uveal melanomas; ocular melanocytosis; gene expression ... See more keywords
Mapping Sentinel Vessels in Uveal Melanomas Using Laser Speckle Contrast Imaging
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DOI: 10.1159/000541715
Abstract: Abstract Introduction: Sentinel vessels provide an important early indication of underlying ocular neoplasm. To date, there is no noninvasive technique available for imaging and mapping of their vascular supply, which remains largely unstudied. We aimed… read more here.
Keywords: laser speckle; sentinel; sentinel vessels; vessels uveal ... See more keywords
Expression of EZH2 in uveal melanomas patients and associations with prognosis
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DOI: 10.18632/oncotarget.19462
Abstract: Purpose To analyze the prognostic value and potential target for therapeutic intervention of enhancer of zeste homologue 2 (EZH2) in uveal melanomas (UM) patients. Method We analyzed EZH2 expression in 89 primary UM patients by… read more here.
Keywords: ezh2 uveal; melanomas patients; uveal melanomas; ezh2 ... See more keywords
Early treatment and toxicity outcomes for small posterior uveal melanomas treated using custom loaded eye plaques
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2023.1055141
Abstract: Introduction Iodine-125 loaded Collaborative Ocular Melanoma Study plaques can achieve excellent tumor control for patients diagnosed with uveal melanomas. Our ocular cancer team hypothesized that use of novel, partially loaded COMS plaques could ease and… read more here.
Keywords: small posterior; uveal melanomas; loaded plaques; patients treated ... See more keywords
Histopathologic and MR Imaging Appearance of Spontaneous and Radiation-Induced Necrosis in Uveal Melanomas: Initial Results
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DOI: 10.3390/cancers14010215
Abstract: Simple Summary Uveal melanomas may undergo necrosis, both spontaneously or following radiotherapy. Nowadays radiotherapy is the preferred treatment, whereas enucleation of the eye is used in selected cases. In order to differentiate the effects of… read more here.
Keywords: necrosis; enucleation; appearance; radiation induced ... See more keywords
Microdissection of Distinct Morphological Regions Within Uveal Melanomas Identifies Novel Drug Targets
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DOI: 10.3390/cancers16244152
Abstract: Simple Summary Separately sequencing morphologically distinct regions within large, high-risk uveal melanomas provides deeper insights into tumour biology and identifies additional targets for therapy. Uveal melanomas are rare intraocular malignancies that exhibit significant heterogeneity, with… read more here.
Keywords: distinct morphological; microdissection distinct; morphological regions; uveal melanomas ... See more keywords
EPHA2, EPHA4, and EPHA6 Expression in Uveal Melanomas: Searching for the Culprits of Neoplasia
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12051025
Abstract: Uveal melanomas (UMs) comprise the most common primary intraocular malignancies in adults, with the eye representing the second most common site for melanoma, following the skin. Prognosis remains poor, with approximately half of the cases… read more here.
Keywords: epha2 epha4; uveal melanomas; epha4 epha6; expression ... See more keywords