Development of a radioligand for imaging V1a vasopressin receptors with PET.
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DOI: 10.1016/j.ejmech.2017.08.037
Abstract: A series of vasopressin receptor V1a ligands have been synthesized for positron emission tomography (PET) imaging. The lead compound (1S,5R)-1 ((4-(1H-indol-3-yl)-3-methoxyphenyl) ((1S,5R)-1,3,3-trimethyl-6-azabicyclo[3.2.1]octan-6-yl)methanone) and its F-ethyl analog 6c exhibited the best combination of high binding affinity… read more here.
Keywords: vasopressin receptors; v1a vasopressin; radioligand imaging; development radioligand ... See more keywords