Atg5 Disassociates the V1V0-ATPase to Promote Exosome Production and Tumor Metastasis Independent of Canonical Macroautophagy.
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DOI: 10.1016/j.devcel.2017.11.018
Abstract: Autophagy and autophagy-related genes (Atg) have been attributed prominent roles in tumorigenesis, tumor growth, and metastasis. Extracellular vesicles called exosomes are also implicated in cancer metastasis. Here, we demonstrate that exosome production is strongly reduced… read more here.
Keywords: v1v0 atpase; atg5; metastasis; exosome production ... See more keywords