Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110436
Abstract: HIV-1 clade C envelope immunogens that elicit both neutralizing and non-neutralizing V1V2-scaffold-specific antibodies (protective correlates from RV144 human trial) are urgently needed due to the prevalence of this clade in the most impacted regions worldwide.… read more here.
Keywords: scaffold antibodies; clade; autologous neutralizing; v1v2 scaffold ... See more keywords
Induction of cross-reactive HIV-1 specific antibody responses by engineered V1V2 immunogens with reduced conformational plasticity
Sign Up to like & getrecommendations! Published in 2020 at "Vaccine"
DOI: 10.1016/j.vaccine.2020.03.010
Abstract: Highlights • K155M stabilizes V1V2 β-strand conformation relevant to broad antibody recognition.• β-strand stabilized V1V2 immunogens elicit antibody responses with greater cross-reactivity.• Fine-tuning immunogen conformation modulates immunogenicity. read more here.
Keywords: antibody; v1v2 immunogens; v1v2; induction cross ... See more keywords
Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies
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DOI: 10.7554/elife.27389
Abstract: The HIV-1 envelope (Env) glycoprotein binds to host cell receptors to mediate membrane fusion. The prefusion Env trimer is stabilized by V1V2 loops that interact at the trimer apex. Broadly neutralizing antibodies (bNAbs) against V1V2… read more here.
Keywords: env trimer; hiv envelope; recognition; v1v2 ... See more keywords