Induction of cross-reactive HIV-1 specific antibody responses by engineered V1V2 immunogens with reduced conformational plasticity
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DOI: 10.1016/j.vaccine.2020.03.010
Abstract: Highlights • K155M stabilizes V1V2 β-strand conformation relevant to broad antibody recognition.• β-strand stabilized V1V2 immunogens elicit antibody responses with greater cross-reactivity.• Fine-tuning immunogen conformation modulates immunogenicity. read more here.
Keywords: antibody; v1v2 immunogens; v1v2; induction cross ... See more keywords