Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
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DOI: 10.1038/s41401-021-00818-x
Abstract: Dipeptidyl peptidase-4 (DPP4) plays a crucial role in regulating the bioactivity of glucagon-like peptide-1 (GLP-1) that enhances insulin secretion and pancreatic β-cell proliferation, making it a therapeutic target for type 2 diabetes. Although the crystal… read more here.
Keywords: v486m; dpp4; activity dpp4; mutation ... See more keywords