Identification of Pyridinyltriazine Derivatives as Potent panFGFR Inhibitors against Gatekeeper Mutants for Overcoming Drug Resistance.
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DOI: 10.1021/acs.jmedchem.1c01776
Abstract: Although FGFR inhibitors hold promise in treating various cancers, resistance to the FGFR inhibitors caused by acquired secondary mutations has emerged. To discover novel FGFR inhibitors capable of inhibiting FGFR mutations, including gatekeeper mutations, we… read more here.
Keywords: fgfr inhibitors; pyridinyltriazine derivatives; identification pyridinyltriazine; potent panfgfr ... See more keywords