JAK1 Pseudokinase V666G Mutant Dominantly Impairs JAK3 Phosphorylation and IL-2 Signaling
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DOI: 10.3390/ijms24076805
Abstract: Overactive Janus kinases (JAKs) are known to drive leukemia, making them well-suited targets for treatment. We sought to identify new JAK-activating mutations and instead found a JAK1-inactivating pseudokinase mutation, V666G. In contrast to other pseudokinase… read more here.
Keywords: jak kinases; jak1 pseudokinase; v666g; pseudokinase ... See more keywords