Imipenem–Relebactam and Meropenem–Vaborbactam: Two Novel Carbapenem-β-Lactamase Inhibitor Combinations
Sign Up to like & getrecommendations! Published in 2017 at "Drugs"
DOI: 10.1007/s40265-017-0851-9
Abstract: Relebactam (formerly known as MK-7655) is a non-β-lactam, bicyclic diazabicyclooctane, β-lactamase inhibitor that is structurally related to avibactam, differing by the addition of a piperidine ring to the 2-position carbonyl group. Vaborbactam (formerly known as… read more here.
Keywords: imipenem; vaborbactam; imipenem relebactam; meropenem vaborbactam ... See more keywords
In vitro activity of meropenem combined with vaborbactam against KPC-producing Enterobacteriaceae in China
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DOI: 10.1093/jac/dky251
Abstract: Background Vaborbactam is a novel inhibitor of serine β-lactamases, including KPCs, which predominate in China. It is being developed in combination with meropenem. Methods Using the broth microdilution method, the in vitro activity of meropenem/vaborbactam… read more here.
Keywords: vaborbactam; producing enterobacteriaceae; meropenem; activity ... See more keywords
Structural Basis and Binding Kinetics of Vaborbactam in Class A β-Lactamase Inhibition
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DOI: 10.1128/aac.00398-20
Abstract: Class A β-lactamases are a major cause of β-lactam resistance in Gram-negative bacteria. The recently FDA-approved cyclic boronate vaborbactam is a reversible covalent inhibitor of class A β-lactamases, including CTX-M extended-spectrum β-lactamase and KPC carbapenemase,… read more here.
Keywords: ctx; binding kinetics; lactamase; class lactamases ... See more keywords
Activity of Meropenem-Vaborbactam in Mouse Models of Infection Due to KPC-Producing Carbapenem-Resistant Enterobacteriaceae
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DOI: 10.1128/aac.01446-17
Abstract: ABSTRACT Meropenem-vaborbactam (Vabomere) is highly active against Gram-negative pathogens, especially Klebsiella pneumoniae carbapenemase (KPC)-producing, carbapenem-resistant Enterobacteriaceae. The objective of these studies was to evaluate the efficacy of meropenem alone and in combination with vaborbactam in… read more here.
Keywords: vaborbactam; meropenem vaborbactam; meropenem; carbapenem resistant ... See more keywords
Structural Characterization of the D179N and D179Y Variants of KPC-2 β-Lactamase: Ω-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam
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DOI: 10.1128/aac.02414-21
Abstract: Klebsiella pneumoniae carbapenemases (KPC-2 and KPC-3) present a global clinical threat, as these β-lactamases confer resistance to carbapenems and oxyimino-cephalosporins. Recent clinically identified KPC variants with substitutions at Ambler position D179, located in the Ω… read more here.
Keywords: vaborbactam; ceftazidime avibactam; resistance; kpc ... See more keywords