Curcuma wenyujin Y. H. Chen et C. Ling n-Butyl alcohol extract inhibits AGS cell Helicobacter pyloriCagA+VacA+ promoted invasiveness by down-regulating caudal type homeobox transcription factor and claudin-2 expression
Sign Up to like & getrecommendations! Published in 2017 at "Chinese Journal of Integrative Medicine"
DOI: 10.1007/s11655-017-2958-y
Abstract: ObjectiveTo investigate the effects and possible mechanisms of action of Curcuma wenyujin Y. H. Chen et C. Ling n-Butyl alcohol extract (CWNAE) on repression of human gastric cancer (GC) AGS cell invasion induced by co-culturing… read more here.
Keywords: vaca; group; expression; hpcaga vaca ... See more keywords
Cryo-EM Analysis Reveals Structural Basis of Helicobacter pylori VacA Toxin Oligomerization.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.03.029
Abstract: Helicobacter pylori colonizes the human stomach and contributes to the development of gastric cancer and peptic ulcer disease. H. pylori secretes a pore-forming toxin called vacuolating cytotoxin A (VacA), which contains two domains (p33 and… read more here.
Keywords: vaca; helicobacter; toxin; oligomerization ... See more keywords
Electrochemical Immunosensor for Detection of H. pylori Secretory Protein VacA on g-C3N4/ZnO Nanocomposite-Modified Au Electrode
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DOI: 10.1021/acsomega.2c03627
Abstract: A g-C3N4/ZnO (graphitic carbon nitride/zinc oxide) nanocomposite-decorated gold electrode was employed to design an antigen–antibody-based electrochemical biosensor to detect Helicobacter pylori specific toxin, vacuolating cytotoxin A (VacA). The thermal condensation method was used to synthesize… read more here.
Keywords: electrode; immunosensor; vaca; c3n4 zno ... See more keywords
Natural history of Helicobacter pylori VacA toxin in human gastric epithelium in vivo: vacuoles and beyond
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DOI: 10.1038/s41598-017-15204-z
Abstract: Uptake, intracellular trafficking and pathologic effects of VacA toxin from Helicobacter pylori have been widely investigated in vitro. However, no systematic analysis investigated VacA intracellular distribution and fate in H. pylori-infected human gastric epithelium in… read more here.
Keywords: vaca; gastric epithelium; toxin; vaca toxin ... See more keywords
Helicobacter pylori promotes inflammatory factor secretion and lung injury through VacA exotoxin-mediated activation of NF-κB signaling
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DOI: 10.1080/21655979.2022.2071011
Abstract: ABSTRACT Previous reports have shown that Helicobacter pylori (H. pylori) infection is associated with respiratory diseases. However, the pathogenesis remains unclear. Vacuolating cytotoxin A (VacA) is a major H. pylori exotoxin. In this study, we… read more here.
Keywords: lung injury; vaca; secretion; factor ... See more keywords
Functional Properties of Oligomeric and Monomeric Forms of Helicobacter pylori VacA Toxin
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DOI: 10.1128/iai.00348-21
Abstract: Helicobacter pylori VacA is a secreted toxin that assembles into water-soluble oligomeric structures and forms anion-selective membrane channels. Acidification of purified VacA enhances its activity in cell culture assays. ABSTRACT Helicobacter pylori VacA is a… read more here.
Keywords: microscopy; helicobacter pylori; activity; vaca ... See more keywords
Helicobacter pylori vacA, cagA and iceA genotypes in dyspeptic patients from southwestern region, Saudi Arabia: distribution and association with clinical outcomes and histopathological changes
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DOI: 10.1186/s12876-019-0934-z
Abstract: BackgroundThe aim of this study was to identify the common H. pylori virulence genes among dyspeptic Southwestern Saudi patients and their association with clinical outcomes and histopathological findings to help practitioners and researchers in the… read more here.
Keywords: outcomes histopathological; clinical outcomes; vaca; icea ... See more keywords
Vacuolating Cytotoxin A Triggers Mitophagy in Helicobacter pylori-Infected Human Gastric Epithelium Cells
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DOI: 10.3389/fonc.2022.881829
Abstract: Helicobacter pylori (H. pylori)-derived vacuolating cytotoxin A (VacA) causes damage to various organelles, including mitochondria, and induces autophagy and cell death. However, it is unknown whether VacA-induced mitochondrial damage can develop into mitophagy. In this… read more here.
Keywords: vaca; vacuolating cytotoxin; membrane; helicobacter pylori ... See more keywords
Oxidative Products of Curcumin Rather Than Curcumin Bind to Helicobacter Pylori Virulence Factor VacA and Are Required to Inhibit Its Vacuolation Activity
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DOI: 10.3390/molecules27196727
Abstract: Curcumin is a hydrophobic polyphenol derived from turmeric with potent anti-oxidant, anti-microbial, anti-inflammatory and anti-carcinogenic effects. Curcumin is degraded into various derivatives under in vitro and in vivo conditions, and it appears that its degradation… read more here.
Keywords: vacuolation activity; curcumin; vaca; factor ... See more keywords
Molecular evolution of the VacA p55 binding domain of Helicobacter pylori in mestizos from a high gastric cancer region of Colombia
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DOI: 10.7717/peerj.6634
Abstract: The stomach bacterium Helicobacter pylori is one of the most prevalent pathogens in humans, closely linked with serious diseases such as gastric cancer. The microbe has been associated with its host for more than 100,000… read more here.
Keywords: evolution; p55; gastric cancer; vaca ... See more keywords