Selective Targeting of Guanine-Vacancy-Bearing G-Quadruplexes by G-Quartet Complementation and Stabilization with a Guanine-Peptide Conjugate.
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DOI: 10.1021/jacs.0c00774
Abstract: Stabilization of G-quadruplexes (G4s) formed in guanine-rich (G-rich) nucleic acids by small-molecule ligands has been extensively explored as a therapeutic approach for diseases such as cancer. Finding ligands with sufficient affinity and specificity towards G4s… read more here.
Keywords: guanine; stabilization; bearing quadruplexes; vacancy bearing ... See more keywords