Rewiring of one carbon metabolism in Salmonella serves as an excellent live vaccine against systemic salmonellosis.
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DOI: 10.1016/j.vaccine.2018.10.079
Abstract: Live attenuated vaccines are superior to the killed or subunit vaccines. We designed a Salmonella Typhimurium strain by deleting folD gene (encoding methylenetetrahydrofolate dehydrogenase-cyclohydrolase) in the presence of a heterologous fhs gene (encoding formyltetrahydrofolate synthetase)… read more here.
Keywords: salmonella; vaccinated cohort; salmonellosis; vaccine ... See more keywords