Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability
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DOI: 10.1016/j.immuni.2019.10.008
Abstract: Summary The elicitation of broadly neutralizing antibodies (bNAbs) against the HIV-1 envelope glycoprotein (Env) trimer remains a major vaccine challenge. Most cross-conserved protein determinants are occluded by self-N-glycan shielding, limiting B cell recognition of the… read more here.
Keywords: envelope; trimer; neutralizing antibodies; vaccination glycan ... See more keywords