Therapeutic vaccination against leukaemia via the sustained release of co-encapsulated anti-PD-1 and a leukaemia-associated antigen.
Sign Up to like & getrecommendations! Published in 2020 at "Nature biomedical engineering"
DOI: 10.1038/s41551-020-00624-6
Abstract: Therapeutic leukaemia vaccines have shown modest potency. Here, we show that the co-encapsulation of a leukaemia-associated epitope peptide highly expressed in leukaemia patients and of the immune checkpoint inhibitor anti-programmed-cell-death-protein-1 (anti-PD-1) in degradable poly(lactic acid)… read more here.
Keywords: leukaemia associated; therapeutic vaccination; sustained release; vaccination leukaemia ... See more keywords