Combining different types of multifunctional liposomes loaded with ammonium bicarbonate to fabricate microneedle arrays as a vaginal mucosal vaccine adjuvant‐dual delivery system (VADDS)
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2016.12.009
Abstract: Abstract To develop effective mucosal vaccines, two types of multifunctional liposomes, the mannosylated lipid A‐liposomes (MLLs) with a size of 200 nm and the stealth lipid A‐liposomes (SLLs) of 50 nm, both loaded with a… read more here.
Keywords: adjuvant dual; multifunctional liposomes; types multifunctional; vaccine adjuvant ... See more keywords
Liposomes used as a vaccine adjuvant-delivery system: From basics to clinical immunization
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2019.04.025
Abstract: Abstract Liposomes are widely utilized as a carrier to improve therapeutic efficacy of agents thanks to their merits of high loading capacity, targeting delivery, reliable protection of agents, good biocompatibility, versatile structure modification and adjustable… read more here.
Keywords: immunization; delivery system; delivery; clinical immunization ... See more keywords
A novel vaccinological evaluation of intranasal vaccine and adjuvant safety for preclinical tests.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2016.12.036
Abstract: Vaccines are administered to healthy humans, including infants, so the safety and efficacy must be very high. Therefore, evaluating vaccine safety in preclinical and clinical studies, according to World Health Organization guidelines, is crucial for… read more here.
Keywords: safety; vaccine adjuvant; evaluation; safety preclinical ... See more keywords
Synthesis and Evaluation of a QS-17/18-Based Vaccine Adjuvant.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01997
Abstract: We have synthesized a QS-17/18 analogue (7) and evaluated its adjuvant activity in the formulation with rHagB antigen. Compound 7 and QS-21 analogues 5 and 6 are presumably the major components of GPI-0100, a widely… read more here.
Keywords: based vaccine; evaluation based; vaccine adjuvant; gpi 0100 ... See more keywords
Metabolic profiling and compound-class identification reveal alterations in serum triglyceride levels in mice immunized with human vaccine adjuvant Alum.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.9b00517
Abstract: Alum has been widely used as an adjuvant for human vaccines; however, the impact of Alum on host metabolism remains largely unknown. Herein, we applied mass spectrometry (LCMS)-based metabolic and lipid profiling to monitor the… read more here.
Keywords: class; adjuvant alum; vaccine adjuvant; human vaccine ... See more keywords
Enhanced Immune Responses to Mucosa by Functionalized Chitosan-Based Composite Nanoparticles as a Vaccine Adjuvant for Intranasal Delivery.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c17627
Abstract: Nasal administration for vaccine delivery is a novel non-invasive vaccine administration approach that can induce local or systemic immune responses and overcome the disadvantages caused by traditional injectable administration. However, mucosal vaccine and adjuvant delivery… read more here.
Keywords: immune responses; hacc cmcs; vaccine adjuvant; delivery ... See more keywords
Vaccine adjuvant activity of a TLR4-activating synthetic glycolipid by promoting autophagy
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DOI: 10.1038/s41598-020-65422-1
Abstract: Toll-like receptors (TLRs) play crucial roles in host immune defenses. Recently, TLR-mediated autophagy is reported to promote immune responses via increasing antigen processing and presentation in antigen presenting cells. The present study examined whether the… read more here.
Keywords: ccl; adjuvant activity; antigen specific; vaccine adjuvant ... See more keywords
Assessment of stability of sulphated lactosyl archaeol archaeosomes for use as a vaccine adjuvant
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DOI: 10.1080/08982104.2020.1786115
Abstract: Abstract Archaeosomes, composed of sulphated lactosyl archaeol (SLA) glycolipids, have been proven to be an effective vaccine adjuvant in multiple preclinical models of infectious disease or cancer. In addition to efficacy, the stability of vaccine… read more here.
Keywords: lactosyl archaeol; vaccine adjuvant; sulphated lactosyl; vaccine ... See more keywords
Aminated nanomicelles as a designer vaccine adjuvant to trigger inflammasomes and multiple arms of the innate immune response in lymph nodes
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s144623
Abstract: In this study, we suggest a designer vaccine adjuvant that can mimic the drainage of pathogens into lymph nodes and activate innate immune response in lymph nodes. By the amination of multivalent carboxyl groups in… read more here.
Keywords: lymph nodes; vaccine adjuvant; designer vaccine; immune response ... See more keywords
Studies on the Use of Flagellin as an Immunostimulant and Vaccine Adjuvant in Fish Aquaculture
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DOI: 10.3389/fimmu.2018.03054
Abstract: Immunostimulants and vaccines are important for controlling infectious diseases in fish aquaculture. In this study we assess the potential of flagellin to be used for such purposes in rainbow trout (Oncorhynchus mykiss). A recombinant flagellin… read more here.
Keywords: flagellin; yrf; immunostimulant vaccine; vaccine adjuvant ... See more keywords
Epigallocatechin-3-Gallate as a Novel Vaccine Adjuvant
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.769088
Abstract: Vaccine adjuvants from natural resources have been utilized for enhancing vaccine efficacy against infectious diseases. This study examined the potential use of catechins, polyphenolic materials derived from green tea, as adjuvants for subunit and inactivated… read more here.
Keywords: vaccine adjuvant; epigallocatechin gallate; gallate novel; novel vaccine ... See more keywords