Thermophobic Trehalose Glycopolymers as Smart C-Type Lectin Receptor Vaccine Adjuvants.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202202918
Abstract: Herein we report the first synthetic vaccine adjuvants that attenuate potency in response to small, 1-2°C, changes in temperature about their Lower Critical Solution Temperature (LCST). Adjuvant additives significantly increase vaccine efficacy. However, adjuvants also… read more here.
Keywords: trehalose glycopolymers; thermophobic trehalose; glycopolymers smart; vaccine adjuvants ... See more keywords
Polysaccharides derived from Chinese medicinal herbs: A promising choice of vaccine adjuvants.
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DOI: 10.1016/j.carbpol.2021.118739
Abstract: Adjuvants have been used in vaccines for a long time to promote the body's immune response, reducing vaccine dosage and production costs. Although many vaccine adjuvants are developed, the use in human vaccines is limited… read more here.
Keywords: polysaccharides derived; chinese medicinal; medicinal herbs; derived chinese ... See more keywords
Design and application of nanoparticles as vaccine adjuvants against human corona virus infection
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Inorganic Biochemistry"
DOI: 10.1016/j.jinorgbio.2021.111454
Abstract: In recent years, some viruses have caused a grave crisis to global public health, especially the human coronavirus. A truly effective vaccine is therefore urgently needed. Vaccines should generally have two features: delivering antigens and… read more here.
Keywords: application nanoparticles; design application; application; vaccine adjuvants ... See more keywords
Polysaccharides as vaccine adjuvants.
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.07.040
Abstract: Adjuvant is a substance added to vaccine to improve the immunogenicity of antigens, and it can induce stronger immune responses and reduce the dosage and production cost of vaccine in populations responding poorly to vaccination.… read more here.
Keywords: polysaccharide adjuvants; vaccine adjuvants; polysaccharides vaccine;
Synthetic Glycolipids as Molecular Vaccine Adjuvants: Mechanism of Action in Human Cells and In Vivo Activity
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DOI: 10.1021/acs.jmedchem.1c00896
Abstract: Modern adjuvants for vaccine formulations are immunostimulating agents whose action is based on the activation of pattern recognition receptors (PRRs) by well-defined ligands to boost innate and adaptive immune responses. Monophosphoryl lipid A (MPLA), a… read more here.
Keywords: synthetic glycolipids; activity; vaccine adjuvants; molecular vaccine ... See more keywords
Vaccine Adjuvants Derivatized from Momordica Saponins I and II.
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DOI: 10.1021/acs.jmedchem.9b01511
Abstract: We have derivatized Momordica saponins (MS) I and II through their coupling at C3 glucuronic acid site with dodecylamine. The derivatives show significantly different immunostimulant activity profiles from their respective natural parent saponins. In particular,… read more here.
Keywords: momordica; derivatized momordica; chemistry; vaccine adjuvants ... See more keywords
Aryl Trehalose Derivatives as Vaccine Adjuvants for Mycobacterium tuberculosis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b01598
Abstract: Despite the ever present need for an efficacious Mycobacterium tuberculosis (Mtb) vaccine, efforts for development have been largely unsuccessful. Correlates of immune protection against Mtb are not wholly defined, but Th1 and likely Th17 adaptive… read more here.
Keywords: aryl trehalose; tuberculosis; vaccine adjuvants; trehalose derivatives ... See more keywords
Alpha-D-glucan-based vaccine adjuvants: Current status and future perspectives
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.858321
Abstract: Nanoparticles (NPs) are increasingly used as efficient vaccine antigen-delivery platforms and vaccine adjuvants. Alpha (α)-D-glucans are polysaccharide polymers found in plants, animals, and microbes. Phytoglycogen (PG) is a densely branched dendrimer-like α-D-glucan that forms nanoparticle… read more here.
Keywords: alpha glucan; glucan based; adjuvants current; vaccine adjuvants ... See more keywords
Vaccine adjuvants to engage the cross-presentation pathway
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DOI: 10.3389/fimmu.2022.940047
Abstract: Adjuvants are indispensable components of vaccines for stimulating optimal immune responses to non-replicating, inactivated and subunit antigens. Eliciting balanced humoral and T cell-mediated immunity is paramount to defend against diseases caused by complex intracellular pathogens,… read more here.
Keywords: presentation pathway; cell; presentation; vaccine adjuvants ... See more keywords
New-age vaccine adjuvants, their development, and future perspective
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DOI: 10.3389/fimmu.2023.1043109
Abstract: In the present scenario, immunization is of utmost importance as it keeps us safe and protects us from infectious agents. Despite the great success in the field of vaccinology, there is a need to not… read more here.
Keywords: age vaccine; vaccine adjuvants; new age; development future ... See more keywords
Research progress in the development of natural-product-based mucosal vaccine adjuvants
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1152855
Abstract: Mucosal vaccines have great potential and advantages in preventing infection caused by multiple pathogens. In developing mucosal vaccines, the biggest challenge comes from finding safe and effective adjuvants and drug delivery systems. Great progress has… read more here.
Keywords: progress; mucosal vaccine; product based; vaccine adjuvants ... See more keywords