Biomaterials for vaccine‐based cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2018.10.008
Abstract: &NA; The development of therapeutic cancer vaccines as a means to generate immune reactivity against tumors has been explored since the early discovery of tumor‐specific antigens by Georg Klein in the 1960s. However, challenges including… read more here.
Keywords: based cancer; vaccine based; biomaterials vaccine; cancer immunotherapy ... See more keywords
Vaccine-Based Immunotherapeutics for the Treatment of Glioblastoma: Advances, Challenges, and Future Perspectives.
Sign Up to like & getrecommendations! Published in 2018 at "World neurosurgery"
DOI: 10.1016/j.wneu.2018.08.202
Abstract: Glioblastoma is a highly aggressive neoplasm with an extremely poor prognosis. Despite maximal gross resection and chemoradiotherapy, these grade IV astrocytomas consistently recur. Glioblastoma cells exhibit numerous pathogenic mechanisms to decrease tumor immunogenicity while promoting… read more here.
Keywords: glioblastoma; vaccine based; challenges future; based immunotherapeutics ... See more keywords
A VACCINE-BASED STRATEGY FOR REDUCING CARDIOVASCULAR DISEASE RISK FACTORS
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(17)35172-0
Abstract: Introduction: Elevated levels of serum LDL-cholesterol (LDL-C) and triglycerides have independently been found to confer increased risk of early cardiovascular disease (CVD). Naturally occurring loss-of-function mutations in two host proteins that are involved in lipid… read more here.
Keywords: strategy reducing; risk; vaccine based; based strategy ... See more keywords
Recent Advances in Immunotherapeutic and Vaccine-Based Approaches for the Treatment of Drug-Resistant Bacterial Infections.
Sign Up to like & getrecommendations! Published in 2025 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.5c00001
Abstract: Antimicrobial resistance poses a grave threat to global public health. Although new antibiotics are urgently needed, most share resistance mechanisms with existing drugs, thereby necessitating the development of alternative antibacterial therapeutics. Various immunotherapeutic agents, including… read more here.
Keywords: resistant bacterial; drug resistant; vaccine based; bacterial infections ... See more keywords
A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15927-0
Abstract: The unsatisfactory response rate of immune checkpoint blockade (ICB) immunotherapy severely limits its clinical application as a tumor therapy. Here, we generate a vaccine-based nanosystem by integrating siRNA for Cd274 into the commercial human papillomavirus… read more here.
Keywords: immunotherapy; vaccine based; innate immunity; based nanosystem ... See more keywords
A broad spectrum Shigella vaccine based on VirG53–353 multiepitope region produced in a cell-free system
Sign Up to like & getrecommendations! Published in 2025 at "NPJ Vaccines"
DOI: 10.1038/s41541-025-01064-6
Abstract: Dysentery caused by Shigella species remains a major health threat to children in low- and middle-income countries. There is no vaccine available. The most advanced candidates, i.e., O-polysaccharide (OPS)-based conjugates, have limited coverage—only against the… read more here.
Keywords: shigella; cell free; shigella vaccine; vaccine based ... See more keywords
A Multivalent Vaccine Based on Ferritin Nanocage Elicits Potent Protective Immune Responses against SARS-CoV-2 Mutations
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23116123
Abstract: The SARS-CoV-2 pandemic has created a global public crisis and heavily affected personal lives, healthcare systems, and global economies. Virus variants are continuously emerging, and, thus, the pandemic has been ongoing for over two years.… read more here.
Keywords: ferritin nanocage; multivalent vaccine; vaccine based; vaccine ... See more keywords
Biodistribution and Adjuvant Effect of an Intranasal Vaccine Based on Chitosan Nanoparticles against Paracoccidioidomycosis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Fungi"
DOI: 10.3390/jof9020245
Abstract: Paracoccidioidomycosis (PCM) is a fungal infection caused by the thermodimorphic Paracoccidioides sp. PCM mainly affects the lungs, but, if it is not contained by the immune response, the disease can spread systemically. An immune response… read more here.
Keywords: biodistribution; chitosan nanoparticles; vaccine based; immune response ... See more keywords
A Single-Component Multilayered Self-Assembling Protein Nanoparticle Vaccine Based on Extracellular Domains of Matrix Protein 2 against Both Influenza A and B
Sign Up to like & getrecommendations! Published in 2024 at "Vaccines"
DOI: 10.3390/vaccines12090975
Abstract: The development of an effective and broadly protective influenza vaccine against circulating and emerging strains remains elusive. In this study, we evaluated a potentially universal influenza vaccine based on single-component self-assembling protein nanoparticles (1c-SApNPs) presenting… read more here.
Keywords: influenza; self assembling; vaccine based; single component ... See more keywords