Preclinical development of a novel Group B Streptococcus (GBS) vaccine candidate for maternal immunization based upon the alpha‐like protein family of GBS surface proteins (Alp)
Sign Up to like & getrecommendations! Published in 2023 at "Birth Defects Research"
DOI: 10.1002/bdr2.2173
Abstract: A novel Group B Streptococcus (GBS) vaccine, based upon the GBS alpha‐like surface proteins, is being developed by MinervaX for administration to pregnant women. The vaccine is intended to generate antibodies (IgG) capable of crossing… read more here.
Keywords: vaccine candidate; gbs; vaccine; surface proteins ... See more keywords
Regeneration of Capto Core 700 resin through high throughput and laboratory scale studies and impact on production of a SARS‐CoV‐2 vaccine candidate
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Journal"
DOI: 10.1002/biot.202200191
Abstract: During the development of a SARS‐CoV‐2 vaccine candidate, at the height of the COVID‐19 pandemic, raw materials shortages, including chromatography resins, necessitated the determination of a cleaning in place (CIP) strategy for a multimodal core‐shell… read more here.
Keywords: core; vaccine candidate; resin; capto core ... See more keywords
Development of a replication‐deficient adenoviral vector‐based vaccine candidate for the interception of HPV16‐ and HPV18‐induced infections and disease
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Cancer"
DOI: 10.1002/ijc.30679
Abstract: High‐risk Human papilloma virus (HPV) types are the causative agents of cervical cancer and several other anogenital malignancies. The viral proteins expressed in the (pre)malignant cells are considered ideal targets for immunological intervention. Many approaches… read more here.
Keywords: replication deficient; hpv16 hpv18; vaccine candidate; disease ... See more keywords
Application of Fmoc-SPPS, Thiol-Maleimide Conjugation, and Copper(I)-Catalyzed Alkyne-Azide Cycloaddition "Click" Reaction in the Synthesis of a Complex Peptide-Based Vaccine Candidate Against Group A Streptococcus.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0227-0_2
Abstract: Fmoc solid-phase peptide synthesis (SPPS) is the most common approach used to synthesize natural and unnatural peptides. However, the synthesis of sequences longer than 30-60 amino acids is associated with a drastic reduction in peptide… read more here.
Keywords: candidate group; group streptococcus; vaccine candidate; fmoc spps ... See more keywords
Designing a next generation multi-epitope based peptide vaccine candidate against SARS-CoV-2 using computational approaches
Sign Up to like & getrecommendations! Published in 2021 at "3 Biotech"
DOI: 10.1007/s13205-020-02574-x
Abstract: COVID-19 caused by SARS-CoV-2 was declared a global pandemic by WHO (World Health Organization) in March, 2020. Within 6 months, nearly 750,000 deaths are claimed by COVID-19 across the globe. This called for immediate social,… read more here.
Keywords: vaccine; sars cov; vaccine candidate; immune response ... See more keywords
F18+Escherichia coli flagellin expression in Salmonella has immunoadjuvant effects in a ghost vaccine candidate containing E. coli Stx2eB, FedF and FedA against porcine edema disease.
Sign Up to like & getrecommendations! Published in 2018 at "Comparative immunology, microbiology and infectious diseases"
DOI: 10.1016/j.cimid.2018.08.003
Abstract: Flagellin, a major structural component of bacteria flagella, is responsible for facilitating motility and invading host cells. The binding capacity of flagellin to toll-like receptor 5 (TLR5) and its trigger action for innate immunity make… read more here.
Keywords: candidate; vaccine candidate; ghost vaccine; expression ... See more keywords
Physicochemical studies on the structural stability of the HIV-1 vaccine candidate recombinant Tat protein.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.07.141
Abstract: HIV-1 transactivator of transcription protein is one of the most promising AIDS vaccine candidates and plays central roles in the virus life cycle and pathogenesis. Understanding structural properties of vaccine candidate antigens leads to rational… read more here.
Keywords: protein; hiv; vaccine candidate; stability ... See more keywords
Characterization of killed but metabolically active uropathogenic Escherichia coli strain as possible vaccine candidate for urinary tract infection.
Sign Up to like & getrecommendations! Published in 2018 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2018.06.027
Abstract: BACKGROUND AND AIM Urinary tract infection (UTI) is the second most frequent infection in human, and uropathogenic Escherichia coli is its most common cause. Although antibiotics are the standard treatment for UTI, they can cause… read more here.
Keywords: urinary tract; candidate; infection; vaccine candidate ... See more keywords
A novel approach for construction of an inactivated typhoid vaccine candidate that effectively augments both humoral and cellular immune responses.
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DOI: 10.1016/j.vaccine.2017.04.084
Abstract: Salmonella enterica serovar Typhi ghost was constructed as a vaccine candidate against typhoid fever. An asd+ plasmid pJHL187 harboring a ghost cassette comprised of PhiX 174 E lysis gene stringently controlled under the convergent promotor… read more here.
Keywords: candidate; vaccine candidate; immunized mice; novel approach ... See more keywords
Penton base induces better protective immune responses than fiber and hexon as a subunit vaccine candidate against adenoviruses.
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.05.118
Abstract: Human adenoviruses (AdVs) have been extensively studied as vectors for gene therapy and vaccination. However, little attention has been paid to AdV vaccine development and treatment. Currently, there is a lack of information concerning the… read more here.
Keywords: penton base; ppenton; vaccine candidate; fiber hexon ... See more keywords
An in vitro functional assay to measure the biological activity of TB vaccine candidate H4-IC31.
Sign Up to like & getrecommendations! Published in 2019 at "Vaccine"
DOI: 10.1016/j.vaccine.2019.04.035
Abstract: Potency assays for vaccine products are an important regulatory requirement, and are used to assess product quality and consistency prior to lot release for clinical testing. Ideally they measure an established correlate of efficacy or… read more here.
Keywords: ic31; vaccine candidate; measure; candidate ic31 ... See more keywords