In-Silico Immunoinformatic analysis of SARS-CoV-2 virus for the development of putative vaccine construct
Sign Up to like & getrecommendations! Published in 2021 at "Immunobiology"
DOI: 10.1016/j.imbio.2021.152134
Abstract: COVID-19 (CoronaVirus disease 2019) is caused by the SARS-CoV-2 virus (severe acute respiratory syndrome corona virus 2). SARS-CoV-2 virus is highly contagious and affects the human respiratory tract resulting in symptoms such as high fever,… read more here.
Keywords: vaccine; sars cov; vaccine construct; cov virus ... See more keywords
Design of a multi-epitope subunit vaccine for immune-protection against Leishmania parasite
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DOI: 10.1080/20477724.2020.1842976
Abstract: ABSTRACT Visceral Leishmaniasis (VL) is an insect-borne neglected disease caused by the protozoan parasite Leishmania donovani. In the absence of a commercial vaccine against VL, chemotherapy is currently the only option used for the treatment… read more here.
Keywords: vaccine; vaccine construct; design multi; multi epitope ... See more keywords
In silico Design of a Vaccine Candidate for SAR S-CoV-2 Based on Multiple T-cell and B-cell Epitopes.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of Razi Institute"
DOI: 10.22092/ari.2020.351605.1526
Abstract: Coronaviruses (2019-nCoV) are large single-stranded RNA viruses that usually cause respiratory infections with a crude lethality ratio of 3.8% and high levels of transmissibility. There is yet no applicable clinical evaluation to assess the efficacy… read more here.
Keywords: vaccine construct; cell cell; cell epitopes; cell ... See more keywords
Designing mRNA- and Peptide-Based Vaccine Construct against Emerging Multidrug-Resistant Citrobacter freundii: A Computational-Based Subtractive Proteomics Approach
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DOI: 10.3390/medicina58101356
Abstract: Background and Objectives: Citrobacter freundii (C. freundii) is an emerging and opportunistic Gram-negative bacteria of the human gastrointestinal tract associated with nosocomial and severe respiratory tract infections. It has also been associated with pneumonia, bloodstream,… read more here.
Keywords: computational based; multidrug resistant; citrobacter freundii; vaccine construct ... See more keywords
Designing Novel Multi-Epitope Vaccine Construct against Prevotella intermedia-Interpain A: An Immunoinformatics Approach
Sign Up to like & getrecommendations! Published in 2023 at "Medicina"
DOI: 10.3390/medicina59020302
Abstract: Background and Objectives: Periodontitis is a chronic multifactorial inflammatory infectious disease marked by continuous degradation of teeth and surrounding parts. One of the most important periodontal pathogens is P. intermedia, and with its interpain A… read more here.
Keywords: epitope vaccine; multi epitope; vaccine construct; intermedia interpain ... See more keywords
Synthesis and Immunological Evaluation of a Single Molecular Construct MUC1 Vaccine Containing l-Rhamnose Repeating Units
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25143137
Abstract: A rhamnose targeting strategy for generating effective anticancer vaccines was successful in our previous studies. We showed that by utilizing natural anti-rhamnose antibodies, a rhamnose-containing vaccine can be targeted to antigen-presenting cells, such as dendritic… read more here.
Keywords: construct; muc1; component vaccine; antigen ... See more keywords
Design and Immunoinformatic Assessment of Candidate Multivariant mRNA Vaccine Construct against Immune Escape Variants of SARS-CoV-2
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DOI: 10.3390/polym14163263
Abstract: To effectively counter the evolving threat of SARS-CoV-2 variants, modifications and/or redesigning of mRNA vaccine construct are essentially required. Herein, the design and immunoinformatic assessment of a candidate novel mRNA vaccine construct, DOW-21, are discussed.… read more here.
Keywords: immune escape; sars cov; mrna vaccine; vaccine construct ... See more keywords
mRNA Vaccine Designing Using Chikungunya Virus E Glycoprotein through Immunoinformatics-Guided Approaches
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DOI: 10.3390/vaccines10091476
Abstract: Chikungunya virus is an alphavirus transmitted by mosquitos that develops into chikungunya fever and joint pain in humans. This virus’ name originated from a Makonde term used to describe an illness that changes the joints… read more here.
Keywords: mrna vaccine; chikungunya virus; vaccine; vaccine construct ... See more keywords
Genome-Based Multi-Antigenic Epitopes Vaccine Construct Designing against Staphylococcus hominis Using Reverse Vaccinology and Biophysical Approaches
Sign Up to like & getrecommendations! Published in 2022 at "Vaccines"
DOI: 10.3390/vaccines10101729
Abstract: Staphylococcus hominis is a Gram-positive bacterium from the staphylococcus genus; it is also a member of coagulase-negative staphylococci because of its opportunistic nature and ability to cause life-threatening bloodstream infections in immunocompromised patients. Gram-positive and… read more here.
Keywords: vaccine; staphylococcus hominis; vaccine construct; antigenic epitopes ... See more keywords
Designing of Peptide Based Multi-Epitope Vaccine Construct against Gallbladder Cancer Using Immunoinformatics and Computational Approaches
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DOI: 10.3390/vaccines10111850
Abstract: Gallbladder cancer (GBC) is an aggressive and difficult to treat biliary tract carcinoma with a poor survival rate. The aim of this study was to design a peptide-based multi-epitope vaccine construct against GBC using immunoinformatics… read more here.
Keywords: peptide based; epitope; vaccine; vaccine construct ... See more keywords
Epitope Identification and Designing a Potent Multi-epitope Vaccine Construct against SARS-CoV-2 Including the Emerging Variants
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Global Infectious Diseases"
DOI: 10.4103/jgid.jgid_96_21
Abstract: Introduction: The emergence of a novel coronavirus in China has turned into a SARS-CoV-2 pandemic with high fatality. As vaccines are developed through various strategies, their immunogenic potential may drastically vary and thus pose several… read more here.
Keywords: epitope vaccine; multi epitope; emerging variants; including emerging ... See more keywords