Adaptation‐Proof SARS‐CoV‐2 Vaccine Design
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202206055
Abstract: Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) surface spike glycoprotein—a major antibody target—is critical for virus entry via engagement of human angiotensin‐converting enzyme 2 (ACE2) receptor. Despite successes with existing vaccines and therapies that… read more here.
Keywords: vaccine design; epitope scaffolds; sars cov; spike protein ... See more keywords
Generation of Variability-Free Reference Proteomes from Pathogenic Organisms for Epitope-Vaccine Design.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0389-5_13
Abstract: Many pathogenic organisms have an inherent ability to rapidly evolve into new variants, which enables them to escape previously existing immune responses. Vaccine design strategies should be aimed to counteract such variability, targeting the conserved… read more here.
Keywords: vaccine design; variability; variability free; pathogenic organisms ... See more keywords
Computational Methodology for Peptide Vaccine Design for Zika Virus: A Bioinformatics Approach.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0389-5_2
Abstract: With the increasing frequency of viral epidemics, vaccines to augment the human immune response system have been the medium of choice to combat viral infections. The tragic consequences of the Zika virus pandemic in South… read more here.
Keywords: zika virus; vaccine; methodology; vaccine design ... See more keywords
Vaccine Design Against Leptospirosis Using an Immunoinformatic Approach.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0389-5_7
Abstract: Vaccination is the best way to prevent the spread of emerging or reemerging infectious disease. Current research for vaccine development is mainly focused on recombinant-, subunit-, and peptide-based vaccine. At this point, immunoinformatics has been… read more here.
Keywords: vaccine design; design leptospirosis; using immunoinformatic; vaccine candidates ... See more keywords
Molecular Characterization of a Vector-Based Candidate Antigen Using the 3'-RACE and Genome Walking Methods and In Silico Analysis of the Correspondent Protein for Vaccine Design and Development.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1884-4_29
Abstract: The main objectives of developing vaccines to prevent malaria transmission are malaria control and preventing the reemergence of the disease in endemic regions. Molecular and in silico characterization of a candidate molecule is the first… read more here.
Keywords: characterization; genome walking; vaccine design; race genome ... See more keywords
Immunoinformatics approach for a novel multi-epitope subunit vaccine design against various subtypes of Influenza A virus.
Sign Up to like & getrecommendations! Published in 2021 at "Immunobiology"
DOI: 10.1016/j.imbio.2021.152053
Abstract: Vaccination is the best strategy for the control and prevention of contagious diseases caused by Influenza A viruses. Extraordinary genetic variability and continual evolvability are responsible for the virus having survival and adaptation to host… read more here.
Keywords: vaccine design; subunit vaccine; immunoinformatics approach; influenza virus ... See more keywords
Conformation of the native HIV-1 envelope protein raises questions for vaccine design
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/d41586-019-01085-x
Abstract: The HIV-1 envelope protein is the target of antibodies that neutralize the virus. A fresh look into the conformational states of this protein relaunches the quest to identify those relevant for vaccine design.Relevance of HIV-1… read more here.
Keywords: protein; vaccine design; hiv; hiv envelope ... See more keywords
Current progress of immunoinformatics approach harnessed for cellular- and antibody-dependent vaccine design
Sign Up to like & getrecommendations! Published in 2018 at "Pathogens and Global Health"
DOI: 10.1080/20477724.2018.1446773
Abstract: Abstract Immunoinformatics plays a pivotal role in vaccine design, immunodiagnostic development, and antibody production. In the past, antibody design and vaccine development depended exclusively on immunological experiments which are relatively expensive and time-consuming. However, recent… read more here.
Keywords: current progress; vaccine design; antibody; vaccine ... See more keywords
Recent trends in next generation immunoinformatics harnessed for universal coronavirus vaccine design
Sign Up to like & getrecommendations! Published in 2022 at "Pathogens and Global Health"
DOI: 10.1080/20477724.2022.2072456
Abstract: ABSTRACT The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has globally devastated public health, the economies of many countries and quality of life universally. The… read more here.
Keywords: vaccine design; coronavirus vaccine; design; next generation ... See more keywords
COVID-19 vaccine design using reverse and structural vaccinology, ontology-based literature mining and machine learning
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac190
Abstract: Rational vaccine design, especially vaccine antigen identification and optimization, is critical to successful and efficient vaccine development against various infectious diseases including coronavirus disease 2019 (COVID-19). In general, computational vaccine design includes three major stages:… read more here.
Keywords: vaccine design; machine learning; ontology; vaccinology ... See more keywords
Classification of self-assembling protein nanoparticle architectures for applications in vaccine design
Sign Up to like & getrecommendations! Published in 2017 at "Royal Society Open Science"
DOI: 10.1098/rsos.161092
Abstract: We introduce here a mathematical procedure for the structural classification of a specific class of self-assembling protein nanoparticles (SAPNs) that are used as a platform for repetitive antigen display systems. These SAPNs have distinctive geometries… read more here.
Keywords: classification; self assembling; vaccine design; assembling protein ... See more keywords