Estimation of vaccine efficacy for variants that emerge after the placebo group is vaccinated
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9405
Abstract: SARS‐CoV‐2 continues to evolve and the vaccine efficacy against variants is challenging to estimate. It is now common in phase III vaccine trials to provide vaccine to those randomized to placebo once efficacy has been… read more here.
Keywords: efficacy; placebo group; vaccine efficacy; vaccination ... See more keywords
Intention-to-prevent analyses for estimating human papillomavirus vaccine efficacy in clinical studies
Sign Up to like & getrecommendations! Published in 2017 at "Contemporary Clinical Trials Communications"
DOI: 10.1016/j.conctc.2017.07.010
Abstract: HPV vaccine efficacy trials have been conducted in populations exposed to HPV infection (i.e., sexually active individuals); participants were not excluded from participating in the trials based on their HPV status at baseline. Thus, some… read more here.
Keywords: vaccine efficacy; hpv; intention prevent; efficacy ... See more keywords
SARS-CoV-2 vaccines: Clinical endpoints and psychological perspectives: A literature review
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Infection and Public Health"
DOI: 10.1016/j.jiph.2022.03.017
Abstract: Background About 270 million cases have been confirmed, and 5.3 million fatalities Worldwide due to SARS-CoV-2. Several vaccine candidates have entered phase 3 of the clinical trial and are being investigated to provide immunity to… read more here.
Keywords: review; efficacy; vaccine efficacy; clinical endpoints ... See more keywords
Cricket paralysis virus internal ribosome entry site-derived RNA promotes conventional vaccine efficacy by enhancing a balanced Th1/Th2 response
Sign Up to like & getrecommendations! Published in 2019 at "Vaccine"
DOI: 10.1016/j.vaccine.2019.07.070
Abstract: Abstract An ideal adjuvant should increase vaccine efficacy through balanced Th1/Th2 responses and be safe to use. Recombinant protein-based vaccines are usually formulated with aluminum (alum)-based adjuvants to ensure an adequate immune response. However, use… read more here.
Keywords: vaccine efficacy; th1 th2; balanced th1; efficacy ... See more keywords
Efficacy of a rational algorithm to assess allergy risk in patients receiving the BNT162b2 vaccine.
Sign Up to like & getrecommendations! Published in 2021 at "Vaccine"
DOI: 10.1016/j.vaccine.2021.09.048
Abstract: Among 6146 hospital employees, 118 subjects with severe allergic background were identified through a screening questionnaire and stratified into 3 groups (Low-risk (LR), Intermediate (IR) and High-risk (HR) group), based on their allergic anamnesis. Data… read more here.
Keywords: risk; allergic background; vaccine efficacy; severe allergic ... See more keywords
Vertical transmission of ALV from ALV-J positive parents caused severe immunosuppression and significantly reduced marek's disease vaccine efficacy in three-yellow chickens.
Sign Up to like & getrecommendations! Published in 2020 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2020.108683
Abstract: In order to evaluate the influence of the vertical transmission of avian leukosis virus (ALV) from J subgroup (ALV-J) positive parents on the vaccine efficacy of Marek's disease virus (MDV), ALV-J positive male breeders ×… read more here.
Keywords: alv positive; marek disease; vaccine efficacy; vertical transmission ... See more keywords
Changepoint inference in the presence of missing covariates for principal surrogate evaluation in vaccine trials
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DOI: 10.1093/biomet/asaa100
Abstract: We consider the use of threshold-based regression models to evaluate immune response biomarkers as principal surrogate markers of a vaccine’s protective effect. Threshold-based regression models, which allow the relationship between a clinical outcome and a… read more here.
Keywords: vaccine efficacy; missing covariates; principal surrogate; vaccine ... See more keywords
292 The effect of pharmacological zinc on oral Salmonella vaccine efficacy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Animal Science"
DOI: 10.1093/jas/skaa054.183
Abstract: Pharmacological zinc (2,000-3,000 ppm) is commonly fed to nursery pigs to improve health and growth due to its antimicrobial and anti-inflammatory properties. The objective was to test if pharmacological zinc at time of oral Salmonella… read more here.
Keywords: salmonella; zinc; oral salmonella; vaccine efficacy ... See more keywords
Vaccine efficacy trials for Crimean-Congo haemorrhagic fever: insights from modelling different epidemiological settings
Sign Up to like & getrecommendations! Published in 2022 at "Vaccine"
DOI: 10.1101/2022.06.09.22276201
Abstract: Background: Crimean-Congo haemorrhagic fever (CCHF) is a priority emerging pathogen for which a licensed vaccine is not yet available. We aim to assess the feasibility of conducting phase III vaccine efficacy trials and the role… read more here.
Keywords: crimean congo; efficacy trials; vaccine efficacy; trial ... See more keywords
Discussion on “estimating vaccine efficacy over time after a randomized study is unblinded” by Anastasios A. Tsiatis and Marie Davidian
Sign Up to like & getrecommendations! Published in 2021 at "Biometrics"
DOI: 10.1111/biom.13541
Abstract: Evaluation of COVID-19 vaccines has proceeded at unprecedented speed and required the quick development of statistical methods to emerging challenges in design and analysis. Amajor issue emerged shortly after the trials started enrolling. What to… read more here.
Keywords: time; vaccine efficacy; estimating vaccine; efficacy ... See more keywords
Influenza vaccine efficacy in young children attending childcare: A randomised controlled trial
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Paediatrics and Child Health"
DOI: 10.1111/jpc.13313
Abstract: Influenza causes a substantial burden in young children. Vaccine efficacy (VE) data are limited in this age group. We examined trivalent influenza vaccine (TIV) efficacy and safety in young children attending childcare. read more here.
Keywords: influenza vaccine; vaccine efficacy; children attending; efficacy ... See more keywords