A rationally designed oral vaccine induces immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants.
Sign Up to like & getrecommendations! Published in 2021 at "Nature microbiology"
DOI: 10.1038/s41564-021-00911-1
Abstract: The ability of gut bacterial pathogens to escape immunity by antigenic variation-particularly via changes to surface-exposed antigens-is a major barrier to immune clearance1. However, not all variants are equally fit in all environments2,3. It should… read more here.
Keywords: induces immunoglobulin; oral vaccine; vaccine induces; antigen ... See more keywords
Circular RNA vaccine induces potent T cell responses
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2302191120
Abstract: Significance Circular RNAs (circRNAs) are a unique class of RNAs that are highly stable compared to linear mRNAs and can be engineered to provide durable protein expression. This study demonstrates that circRNA encoding antigenic protein… read more here.
Keywords: potent cell; cell responses; rna vaccine; vaccine induces ... See more keywords