Generalized Modules for Membrane Antigens (GMMA), an outer membrane vesicle‐based vaccine platform, for efficient viral antigen delivery
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12247
Abstract: Abstract Vaccine platforms enable fast development, testing, and manufacture of more affordable vaccines. Here, we evaluated Generalized Modules for Membrane Antigens (GMMA), outer membrane vesicles (OMVs) generated by genetically modified Gram‐negative bacteria, as a vaccine… read more here.
Keywords: vaccine platform; platform; generalized modules; membrane antigens ... See more keywords
Display of HIV-1 Envelope Protein on Lambda Phage Scaffold as a Vaccine Platform.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6869-5_14
Abstract: The generation of a strong antibody response to target antigens is a major goal for vaccine development. Here we describe the display of the human immunodeficiency virus (HIV) envelope spike protein (Env) on a virus-like… read more here.
Keywords: phage; hiv envelope; display; vaccine platform ... See more keywords
Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03847-z
Abstract: Secretion of extracellular vesicles (EVs), a process common to eukaryotes, archae, and bacteria, represents a secretory pathway that allows cell-free intercellular communication. Microbial EVs package diverse proteins and influence the host-pathogen interaction, but the mechanisms… read more here.
Keywords: extracellular vesicles; staphylococcus aureus; vaccine platform;
VelcroVax: a “Bolt-On” Vaccine Platform for Glycoprotein Display
Sign Up to like & getrecommendations! Published in 2023 at "mSphere"
DOI: 10.1128/msphere.00568-22
Abstract: The hepatitis B core protein (HBc) forms noninfectious virus-like particles, which can be modified to present a capturing molecule, allowing suitably tagged antigens to be bound on their surface. This system can be adapted and… read more here.
Keywords: system; vaccine platform; platform; modified present ... See more keywords
Nod2 is required for antigen-specific humoral responses against antigens orally delivered using a recombinant Lactobacillus vaccine platform
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0196950
Abstract: Safe and efficacious orally-delivered mucosal vaccine platforms are desperately needed to combat the plethora of mucosally transmitted pathogens. Lactobacillus spp. have emerged as attractive candidates to meet this need and are known to activate the… read more here.
Keywords: vaccine; humoral responses; vaccine platform; antigen specific ... See more keywords
Integrase-Defective Lentiviral Vector Is an Efficient Vaccine Platform for Cancer Immunotherapy
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13020355
Abstract: Integrase-defective lentiviral vectors (IDLVs) have been used as a safe and efficient delivery system in several immunization protocols in murine and non-human primate preclinical models as well as in recent clinical trials. In this work,… read more here.
Keywords: integrase defective; defective lentiviral; vaccine platform; cancer immunotherapy ... See more keywords
Nucleic Acid Vaccine Platform for DENGUE and ZIKA Flaviviruses
Sign Up to like & getrecommendations! Published in 2022 at "Vaccines"
DOI: 10.3390/vaccines10060834
Abstract: Dengue virus and Zika virus are mosquito-borne, single-stranded, positive-sense RNA viruses that belong to the Flaviviridae family. Both the viruses are closely related and have similarities with other flaviviruses. Dengue virus (DENV) causes a severe… read more here.
Keywords: acid vaccine; vaccine platform; dengue; nucleic acid ... See more keywords
COVID-19 Vaccines (Revisited) and Oral-Mucosal Vector System as a Potential Vaccine Platform
Sign Up to like & getrecommendations! Published in 2021 at "Vaccines"
DOI: 10.3390/vaccines9020171
Abstract: There are several emerging strategies for the vaccination of COVID-19 (SARS-CoV-2) however, only a few have yet shown promising effects. Thus, choosing the right pathway and the best prophylactic options in preventing COVID-19 is still… read more here.
Keywords: vector system; covid vaccines; oral mucosal; covid ... See more keywords