Rapid Development of an Integrated Network Infrastructure to Conduct Phase 3 COVID-19 Vaccine Trials.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2022.51974
Abstract: Importance The COVID-19 pandemic has caused millions of infections and deaths and resulted in unprecedented international public health social and economic crises. As SARS-CoV-2 spread across the globe and its impact became evident, the development… read more here.
Keywords: vaccine trials; development; covid; phase ... See more keywords
Interest in COVID-19 vaccine trials participation among young adults in China: Willingness, reasons for hesitancy, and demographic and psychosocial determinants
Sign Up to like & getrecommendations! Published in 2021 at "Preventive Medicine Reports"
DOI: 10.1016/j.pmedr.2021.101350
Abstract: With the demand for rapid COVID-19 vaccine development and evaluation, this paper aimed to describe the prevalence and correlates of willingness to participate in COVID-19 vaccine trials among university students in China. A cross-sectional survey… read more here.
Keywords: participation; covid vaccine; vaccine trials; vaccine ... See more keywords
Interpreting challenge data from early phase malaria blood stage vaccine trials
Sign Up to like & getrecommendations! Published in 2018 at "Expert Review of Vaccines"
DOI: 10.1080/14760584.2018.1435278
Abstract: ABSTRACT Introduction: As the quest for an effective blood stage malaria vaccine continues, there is increasing reliance on the use of controlled human malaria infections (CHMI) in non-endemic settings to test vaccine efficacy at the… read more here.
Keywords: data early; malaria; vaccine trials; blood stage ... See more keywords
Estimating the annual risk of infection with Mycobacterium tuberculosis among adolescents in Western Kenya in preparation for TB vaccine trials
Sign Up to like & getrecommendations! Published in 2019 at "BMC Infectious Diseases"
DOI: 10.1186/s12879-019-4314-7
Abstract: BackgroundAdolescents are a prime target group for tuberculosis (TB) vaccine trials that include prevention of infection (POI). The BCG vaccine is given at birth and does not prevent TB infection. TB infection, a critical endpoint… read more here.
Keywords: risk; tuberculosis among; vaccine trials; infection ... See more keywords
The Power of Malaria Vaccine Trials Using Controlled Human Malaria Infection
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DOI: 10.1371/journal.pcbi.1005255
Abstract: Controlled human malaria infection (CHMI) in healthy human volunteers is an important and powerful tool in clinical malaria vaccine development. However, power calculations are essential to obtain meaningful estimates of protective efficacy, while minimizing the… read more here.
Keywords: vaccine trials; controlled human; power; malaria infection ... See more keywords
Comparative Benefits and Risks Associated with Currently Authorized COVID-19 Vaccines
Sign Up to like & getrecommendations! Published in 2022 at "Vaccines"
DOI: 10.3390/vaccines10122065
Abstract: This article provides a systematic assessment of the efficacy, risks, and methodological quality of evidence from five major publicly available vaccine trials. Results from Pfizer-BioNTech mRNA, Moderna-US NIH mRN-1273, AstraZeneca-Oxford ChAdOx1 nCov-19, Gamaleya GamCovidVac (Sputnik… read more here.
Keywords: vaccines comparative; vaccine trials; certainty evidence; benefits risks ... See more keywords