Vaccines Targeting PCSK9: A Promising Alternative to Passive Immunization with Monoclonal Antibodies in the Management of Hyperlipidaemia?
Sign Up to like & getrecommendations! Published in 2018 at "Drugs"
DOI: 10.1007/s40265-018-0915-5
Abstract: Hypercholesterolaemia is frequently observed in patients with cardiovascular diseases (CVD) and is associated with increased mortality. Statin treatment has been the standard of care for reducing low-density lipoprotein cholesterol (LDL-C) to improve cardiovascular outcomes. However,… read more here.
Keywords: monoclonal antibodies; vaccines targeting; targeting pcsk9; pcsk9 ... See more keywords
Synthetic vaccines targeting Mincle through conjugation of trehalose dibehenate.
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DOI: 10.1039/d2cc02100e
Abstract: The covalent fusion of immunostimulatory adjuvants to immunogenic antigens is a promising strategy for the development of effective synthetic vaccines for infectious diseases. Herein, we describe the conjugation of a mycobacterial peptide antigen from the… read more here.
Keywords: vaccines targeting; mincle; conjugation; synthetic vaccines ... See more keywords
Selection of adjuvants for vaccines targeting specific pathogens
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DOI: 10.1080/14760584.2019.1604231
Abstract: ABSTRACT Introduction: Adjuvants form an integral component in most of the inactivated and subunit vaccine formulations. Careful and proper selection of adjuvants helps in promoting appropriate immune responses against target pathogens at both innate and… read more here.
Keywords: specific pathogens; vaccines targeting; adjuvants vaccines; targeting specific ... See more keywords
Vaccines targeting the primary amino acid sequence and conformational epitope of amyloid‐β had distinct effects on neuropathology and cognitive deficits in EAE/AD mice
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DOI: 10.1111/bph.15015
Abstract: Immunotherapeutic intervention is one of the most promising strategies for the prevention and treatment of Alzheimer's disease (AD). Although they showed great success in AD mouse models, the clinical trials of many immune approaches failed… read more here.
Keywords: conformational epitope; eae mice; targeting primary; vaccines targeting ... See more keywords