Organotin Polymers as Antiviral Agents Including Inhibition of Zika and Vaccinia Viruses
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Inorganic and Organometallic Polymers and Materials"
DOI: 10.1007/s10904-019-01250-9
Abstract: The ability to inhibit two important viruses is described. Two groups of polymers exhibited ability to totally inhibit the Zika virus. These polymers are derived from organotin dihalides and camphoric acid and lamivudine. This is… read more here.
Keywords: inhibition zika; organotin polymers; inhibition; vaccinia ... See more keywords
Application of poxvirus K3 ortholog as a positive selection marker for constructing recombinant vaccinia viruses with modified host range
Sign Up to like & getrecommendations! Published in 2020 at "MethodsX"
DOI: 10.1016/j.mex.2020.100918
Abstract: Vaccinia virus is capable of replicating in a wide range of vertebrate animal cells. However, deletion of the two virus host range genes, E3L and K3L, would render replication of the virus abortive in all… read more here.
Keywords: poxvirus ortholog; host range; virus; vaccinia ... See more keywords
Equination (inoculation of horsepox): An early alternative to vaccination (inoculation of cowpox) and the potential role of horsepox virus in the origin of the smallpox vaccine.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2017.11.003
Abstract: For almost 150 years after Edward Jenner had published the "Inquiry" in 1798, it was generally assumed that the cowpox virus was the vaccine against smallpox. It was not until 1939 when it was shown that… read more here.
Keywords: inoculation; vaccinia; horsepox; vaccine ... See more keywords
Ebola virus – prospects for a novel virus-like-particle-expressing modified vaccinia Ankara-based vaccine
Sign Up to like & getrecommendations! Published in 2018 at "Expert Review of Vaccines"
DOI: 10.1080/14760584.2018.1510775
Abstract: The Ebola virus (EBOV) epidemic in West Africa that devastated Guinea, Liberia, and Sierra Leone from 2013 to 2016 became a global public health crisis and claimed over 11,000 human lives [1]. There were no… read more here.
Keywords: vaccinia; ebov; mva; vaccine ... See more keywords
Improvement of In Vivo Expression of Genes Delivered by Self-Amplifying RNA Using Vaccinia Virus Immune Evasion Proteins
Sign Up to like & getrecommendations! Published in 2017 at "Human Gene Therapy"
DOI: 10.1089/hum.2017.121
Abstract: Among nucleic acid–based delivery platforms, self-amplifying RNA (saRNA) vectors are of increasing interest for applications such as transient expression of recombinant proteins and vaccination. saRNA is safe and, due to its capability to amplify intracellularly,… read more here.
Keywords: self amplifying; virus immune; vaccinia; expression ... See more keywords
Elucidating mechanisms of antitumor immunity mediated by live oncolytic vaccinia and heat-inactivated vaccinia
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-002569
Abstract: Background Viral-based immunotherapy can overcome resistance to immune checkpoint blockade (ICB) and fill the unmet needs of many patients with cancer. Oncolytic viruses (OVs) are defined as engineered or naturally occurring viruses that selectively replicate… read more here.
Keywords: heat; antitumor immunity; vaccinia; oncolytic vaccinia ... See more keywords
Generation of novel oncolytic vaccinia virus with improved intravenous efficacy through protection against complement-mediated lysis and evasion of neutralization by vaccinia virus-specific antibodies
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-006024
Abstract: Background Oncolytic virus immunotherapy has revolutionized cancer immunotherapy by efficiently inducing both oncolysis and systemic immune activation. Locoregional administration has been used for oncolytic virus therapy, but its applications to deep-seated cancers have been limited.… read more here.
Keywords: oncolytic vaccinia; vaccinia; vaccinia virus; complement mediated ... See more keywords
Abstract 694: TG6050 an oncolytic vaccinia virus armed with interleukin 12 and anti-CTLA4 antibody induces TME remodeling and strong anti-tumoral responses
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-694
Abstract: Background: By replicating specifically into tumor cells, oncolytic vaccinia viruses (VACV) can turn “cold” tumors “hot” while delivering therapeutic payloads into tumor. Thanks to its large genome capacity, multiple cloning loci, and availability of different… read more here.
Keywords: anti tumoral; vaccinia; anti ctla4; anti ... See more keywords
Abstract PR19: Utilizing novel oncolytic vaccinia virus for selective expression of immunotherapeutic payloads in metastatic tumors
Sign Up to like & getrecommendations! Published in 2020 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm18-pr19
Abstract: The treatment paradigm for patients with metastatic cancer has evolved rapidly with the approval of agents targeting CTLA-4 and the PD-1/L1 immune checkpoint axis. Despite the profound impact these agents have had, they are minimally… read more here.
Keywords: expression; oncolytic vaccinia; immunology; virus ... See more keywords
Humoral Immunity to Primary Smallpox Vaccination: Impact of Childhood versus Adult Immunization on Vaccinia Vector Vaccine Development in Military Populations
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0169247
Abstract: Modified Vaccinia virus has been shown to be a safe and immunogenic vector platform for delivery of HIV vaccines. Use of this vector is of particular importance to the military, with the implementation of a… read more here.
Keywords: vector; immunity; vaccine; smallpox vaccination ... See more keywords
The mismatched nucleotides encoded in vaccinia virus flip-and-flop hairpin telomeres serve an essential role in virion maturation
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010392
Abstract: Poxvirus genomes consist of a linear duplex DNA that ends in short inverted and complementary hairpin structures. These elements also encode loops and mismatches that likely serve a role in genome packaging and perhaps replication.… read more here.
Keywords: role; vaccinia; flip flop; hairpin ... See more keywords