RNF144a induces ERK-dependent cell death under oxidative stress via downregulation of Vaccinia Related Kinase3.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.247304
Abstract: Vaccinia-related kinase 3 (VRK3) has been reported to be a negative regulator of ERK that protects cells from persistent ERK activation and inhibits ERK dependent apoptosis. Here we report that the E3 ligase, RNF144a, promotes… read more here.
Keywords: vrk3; rnf144a; erk dependent; vaccinia related ... See more keywords
Revisiting the roles of VHR/DUSP3 phosphatase in human diseases
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DOI: 10.6061/clinics/2018/e466s
Abstract: Protein tyrosine phosphatases have long been considered key regulators of biological processes and are therefore implicated in the origins of various human diseases. Heterozygosity, mutations, deletions, and the complete loss of some of these enzymes… read more here.
Keywords: roles vhr; phosphatase; human diseases; related phosphatase ... See more keywords