Monocytic myeloid‐derived suppressor cells regulate T‐cell responses against vaccinia virus
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201646797
Abstract: Vaccinia virus (VV) can potently activate NK‐ and T‐cell responses, leading to efficient viral control and generation of long‐lasting protective immunity. However, immune responses against viral infections are often tightly controlled to avoid collateral damage… read more here.
Keywords: myeloid derived; cell responses; infection; mdscs ... See more keywords
Luteolin enhances the antitumor efficacy of oncolytic vaccinia virus that harbors IL‐24 gene in liver cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.23677
Abstract: Interleukin 24 (IL‐24) is an IL‐10 family member and a secreted cytokine characterized by cancer‐targeted toxicity and can activate apoptosis by sensitizing cancer cells to chemotherapy. Cytotoxic effects of luteolin on different types of cancer… read more here.
Keywords: liver cancer; oncolytic vaccinia; cancer cells; cancer ... See more keywords
Construction and Isolation of Recombinant Vaccinia Virus Expressing Fluorescent Proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9593-6_4
Abstract: Vaccinia virus recombinants that express fluorescent proteins have a variety of applications such as the identification of infected cells, efficient screening for genetically modified strains, and molecular characterization of virus replication and spread. The detection… read more here.
Keywords: construction; fluorescent proteins; vaccinia virus; isolation ... See more keywords
Synthesis and antiviral activity of 1-hydroxy-2-(2-hydroxyphenyl)imidazoles against vaccinia virus
Sign Up to like & getrecommendations! Published in 2019 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-019-2467-6
Abstract: Abstract2-(2-Hydroxyplienyl)imidazole derivatives were synthesized and tested for antiviral activity against vaccinia virus in Vero cell culture. 1-Methylimidazole 3-oxides, 1-methoxyimidazoles, and 1H-imidazoles showed no activity, whereas some 1-hydroxyimidazole derivatives hold promise, exhibiting antiviral activity and weak… read more here.
Keywords: activity hydroxy; antiviral activity; vaccinia virus; hydroxy hydroxyphenyl ... See more keywords
Stereotactic body radiation combined with oncolytic vaccinia virus induces potent anti-tumor effect by triggering tumor cell necroptosis and DAMPs.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.09.040
Abstract: Radiation is an integral part of cancer therapy. With the emergence of oncolytic vaccinia virus immunotherapy, it is important to study the combination of radiation and vaccinia virus in cancer therapy. In this study, we… read more here.
Keywords: anti tumor; oncolytic vaccinia; vaccinia virus; tumor ... See more keywords
MAVERICC: Marker-free vaccinia virus engineering of recombinants through in vitro CRISPR/Cas9 cleavage.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.166896
Abstract: Vaccinia virus (VACV)-based vectors are in extensive use as vaccines and cancer immunotherapies. VACV engineering has traditionally relied on homologous recombination between a parental viral genome and a transgene-bearing transfer plasmid, an inefficient process that… read more here.
Keywords: crispr cas9; engineering; biology; vaccinia virus ... See more keywords
Intranasal immunization with recombinant Vaccinia virus Tiantan harboring Zaire Ebola virus gp elicited systemic and mucosal neutralizing antibody in mice.
Sign Up to like & getrecommendations! Published in 2019 at "Vaccine"
DOI: 10.1016/j.vaccine.2019.04.070
Abstract: Accumulating literature revealed that human mucosa was likely one of the important routes for EBOV attachment and further infection. Therefore inducing effective mucosal immune responses play key role in preventing the virus infection. Vaccinia virus… read more here.
Keywords: immunization; immune responses; vaccinia virus; mucosal ... See more keywords
Bovine vaccinia: Inactivated Vaccinia virus vaccine induces protection in murine model.
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2017.03.009
Abstract: Bovine vaccinia (BV), caused by Vaccinia virus (VACV), is a zoonosis characterized by exanthematous lesions on the teats of dairy cows and the milkers' hands. Since 1999, due to the occurrence of many BV outbreaks… read more here.
Keywords: bovine vaccinia; vaccinia virus; murine model; vaccine ... See more keywords
Construction of an attenuated Tian Tan vaccinia virus strain by deletion of TA35R and TJ2R genes.
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DOI: 10.1016/j.virusres.2018.06.017
Abstract: rVTT-TA35-TJ, an attenuated vaccinia virus Tian Tan strain (VTT), was constructed by knocking out two non-essential gene fragments (TA35R and TJ2R) related to virulence, immunomodulation, and host range; and by combining double marker screening with… read more here.
Keywords: tian tan; rvtt ta35; vaccinia virus; ta35r tj2r ... See more keywords
The vaccinia virus based Sementis Copenhagen Vector vaccine against Zika and chikungunya is immunogenic in non-human primates
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DOI: 10.1038/s41541-020-0191-8
Abstract: The Sementis Copenhagen Vector (SCV) is a new vaccinia virus-derived, multiplication-defective, vaccine technology assessed herein in non-human primates. Indian rhesus macaques ( Macaca mulatta ) were vaccinated with a multi-pathogen recombinant SCV vaccine encoding the… read more here.
Keywords: non human; sementis copenhagen; vaccinia virus; vaccine ... See more keywords
NF-κB activation is a turn on for vaccinia virus phosphoprotein A49 to turn off NF-κB activation
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1813504116
Abstract: Significance Vaccinia virus (VACV) encodes many proteins that inhibit innate immunity. For instance, protein A49 inhibits NF-κB activation by binding to β-TrCP. Here we show that A49 is phosphorylated on serine 7 and that this… read more here.
Keywords: vaccinia virus; a49; trcp; activation ... See more keywords