Cell-autonomous Toxoplasma killing program requires Irgm2 but not its microbe vacuolar localization
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DOI: 10.26508/lsa.202000960
Abstract: Irgm2 controls Toxoplasma killing via selective recruitment of Gbp1 and Irgb6 to Toxoplasma parasitophorous vacuoles, whereas its vacuolar localization is dispensable for parasite killing. Interferon-inducible GTPases, such as immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs),… read more here.
Keywords: irgm2; parasite killing; toxoplasma; vacuolar localization ... See more keywords