Myeloid and lymphoid vacuolation in VEXAS syndrome
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DOI: 10.1002/ajh.26098
Abstract: A 70-year-old Chinese male presented with unexplained fever, relapsing polychondritis, macrocytic anemia, acute necrotising lymphadenitis, skin papules that were in keeping histologically with Kikuchi-Fujimoto disease, and pulmonary embolism secondary to extensive unprovoked right lower limb… read more here.
Keywords: vexas syndrome; precursor cell; vacuolation; left vacuolation ... See more keywords
PIKfyve inhibitor cytotoxicity requires AKT suppression and excessive cytoplasmic vacuolation
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2018.08.001
Abstract: &NA; PIKfyve phosphoinositide kinase produces PtdIns(3,5)P2 and PtdIns5P and governs a myriad of cellular processes including cytoskeleton rearrangements and cell proliferation. The latter entails rigorous investigation since the cytotoxicity of PIKfyve inhibition is a potential… read more here.
Keywords: excessive cytoplasmic; pikfyve; cytoplasmic vacuolation; inhibitor ... See more keywords
Cytoplasmic vacuolation with endoplasmic reticulum stress directs sorafenib induced non-apoptotic cell death in hepatic stellate cells
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-82381-3
Abstract: The activated hepatic stellate cells (HSCs) are the major cells that secrete the ECM proteins and drive the pathogenesis of fibrosis in chronic liver disease. Targeting of HSCs by modulating their activation and proliferation has… read more here.
Keywords: vacuolation; cell; sorafenib induced; cell death ... See more keywords
Brain Vacuolation Resulting From Administration of the Type II Ampakine CX717 Is An Artifact Related to Molecular Structure and Chemical Reaction With Tissue Fixative Agents
Sign Up to like & getrecommendations! Published in 2018 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfx277
Abstract: Ampakines are small molecule positive allosteric modulators of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA). One class II ("low impact") ampakine, CX717, has been implicated to have a neurotoxic effect based on findings in nonclinical, long-term toxicity studies.… read more here.
Keywords: ampakine cx717; tissue; vacuolation; cx717 ... See more keywords
Streptococcus pyogenes CAMP factor promotes calcium ion uptake in RAW264.7 cells
Sign Up to like & getrecommendations! Published in 2018 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.12647
Abstract: Streptococcus pyogenes is a bacterium that causes systemic diseases such as pharyngitis and toxic shock syndrome. S. pyogenes produces molecules that inhibit the function of the human immune system, thus allowing growth and spread of… read more here.
Keywords: calcium ion; camp factor; vacuolation; ion ... See more keywords
Cytoplasmic Vacuolation and Tapetal Changes Induced by a Novel Analgesic Agent in Beagle Dogs
Sign Up to like & getrecommendations! Published in 2019 at "Toxicologic Pathology"
DOI: 10.1177/0192623319836678
Abstract: Drug-induced unique cytoplasmic vacuolation was found in the subchronic oral toxicity study of 4-dimethylamino-1-{3-(1-methyl-1H-imidazole-2-yl)propanoyl}piperidine (DMIP), a potential therapeutic agent for neuropathic pain, in beagle dogs. In the first study, DMIP was administered at a dose… read more here.
Keywords: vacuolation tapetal; cytoplasmic vacuolation; beagle dogs; vacuolation ... See more keywords