Deletion of the K1L Gene Results in a Vaccinia Virus That Is Less Pathogenic Due to Muted Innate Immune Responses, yet Still Elicits Protective Immunity
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.00542-17
Abstract: ABSTRACT All viruses strategically alter the antiviral immune response to their benefit. The vaccinia virus (VACV) K1 protein has multiple immunomodulatory effects in tissue culture models of infection, including NF-κB antagonism. However, the effect of… read more here.
Keywords: immune; vacv; infection; vaccinia virus ... See more keywords
Type I interferon-dependent CCL4 is induced by a cGAS/STING pathway that bypasses viral inhibition and protects infected tissue, independent of viral burden
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007778
Abstract: Type I interferons (T1-IFN) are critical in the innate immune response, acting upon infected and uninfected cells to initiate an antiviral state by expressing genes that inhibit multiple stages of the lifecycle of many viruses.… read more here.
Keywords: vacv; cgas; ifn; tissue ... See more keywords
Comparison of the Effectiveness of Transepidemal and Intradermal Immunization of Mice with the Vacinia Virus
Sign Up to like & getrecommendations! Published in 2023 at "Acta Naturae"
DOI: 10.32607/actanaturae.11857
Abstract: The spread of the monkeypox virus infection among humans in many countries outside of Africa, which started in 2022, is now drawing the attention of the medical and scientific communities to the fact that immunization… read more here.
Keywords: inoculation; immunization mice; vacv; mice ... See more keywords
Risk Evaluation for Acute Kidney Injury Induced by the Concomitant Use of Valacyclovir, Analgesics, and Renin–Angiotensin System Inhibitors: The Detection of Signals of Drug–Drug Interactions
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00874
Abstract: Background: Drug-related acute kidney disease is a common side effect of valacyclovir (VACV) treatment. Although analgesics are frequently administered concomitantly with VACV to treat the pain of herpes zoster, the differences between nonsteroidal anti-inflammatory drugs… read more here.
Keywords: vacv; vacv related; related aki; drug ... See more keywords
Enhancing the Immunogenicity of Vaccinia Virus
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DOI: 10.3390/v14071453
Abstract: The conventional live smallpox vaccine based on the vaccinia virus (VACV) cannot be widely used today because it is highly reactogenic. Therefore, there is a demand for designing VACV variants possessing enhanced immunogenicity, making it… read more here.
Keywords: livp a34r; immunogenicity; vaccinia virus; vacv ... See more keywords