Caspase inhibitor z-VAD-FMK increases the survival of hair cells after Actinomycin-D-induced damage in vitro
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DOI: 10.1016/j.neulet.2020.135089
Abstract: Actinomycin-D (Act-D) is a highly effective chemotherapeutic agent that induces apoptosis in systemic tissues. Act-D combined with other chemotherapeutic agents exhibits ototoxic effects and causes hearing impairment. To investigate the potential toxic effects of Act-D… read more here.
Keywords: inhibitor; hair; fmk; damage ... See more keywords
Inhibition of apoptosis by caspase inhibitor Z-VAD-FMK improves cryotolerance of in vitro derived bovine embryos.
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DOI: 10.1016/j.theriogenology.2017.11.031
Abstract: The aim of this work was to evaluate whether the treatment with the pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone (Z-VAD-FMK) during cryopreservation and post-warming in vitro culture improves cryotolerance of bovine in vitro produced (IVP) embryos. Abattoir derived bovine… read more here.
Keywords: caspase; vad fmk; post warming; vad ... See more keywords
Effect of anti-apoptotic drug Z-VAD-FMK on in vitro viability of dog follicles.
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DOI: 10.1016/j.theriogenology.2018.09.012
Abstract: It is recognized that ovarian follicular atresia is associated with apoptosis, and the most important effector of cell death is caspase-3. The aim of this study was to investigate the influence of anti-apoptotic drug Z-VAD-FMK… read more here.
Keywords: anti apoptotic; viability; apoptotic drug; fmk ... See more keywords
Inhibition of Apoptotic Pathways Improves DNA Integrity but Not Developmental Competence of Domestic Cat Immature Vitrified Oocytes
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DOI: 10.3389/fvets.2020.588334
Abstract: Being a model for endangered wild felids, cryopreservation protocols for domestic cat oocytes are under continuous development. Immature vitrified oocytes (VOs) are a valuable resource for fertility preservation programs, but they often degenerate after warming… read more here.
Keywords: caspase; caspase activity; cat; vad fmk ... See more keywords
Blocking of Caspases Exerts Anti-Inflammatory Effects on Periodontal Cells
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DOI: 10.3390/life12071045
Abstract: Periodontitis is an inflammatory process that is associated with caspase activity. Caspases could thus become molecular targets for the modulation of the inflammatory response to harmful factors, such as lipopolysaccharides (LPS) and TNFα. Here, the… read more here.
Keywords: exerts anti; vad fmk; inflammatory response; caspases exerts ... See more keywords