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   Articles with "vaf" as a keyword



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Predictive values of mutational variant allele frequency in overall survival and leukemic progression of myelodysplastic syndromes

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recommendations! Published in 2022 at "Journal of Cancer Research and Clinical Oncology"

DOI: 10.1007/s00432-021-03905-y

Abstract: The implication of mutational variant allelic frequency (VAF) has been increasingly considered in the prognostic interpretation of molecular data in myeloid malignancies. However, the impact of VAF on outcomes of myelodysplastic syndromes (MDS) has not… read more here.

Keywords: vaf; vaf increase; mutational variant; myelodysplastic syndromes ... See more keywords
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Application of ESCAT and OncoKB scales in liquid biopsy (LB) in advanced NSCLC patients (pts): Is it feasible and reliable?

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recommendations! Published in 2019 at "Annals of Oncology"

DOI: 10.1093/annonc/mdz269.013

Abstract: Abstract Background Next generation sequencing (NGS) of cfDNA in NSCLC is entering in clinical practice. Several commercially available platforms using NGS report wide variety of somatic aberrations. Vendors also include therapeutic suggestions to guide oncologists.… read more here.

Keywords: advanced nsclc; escat oncokb; vaf; application escat ... See more keywords
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Serial H3K27M cell-free tumor DNA (cf-tDNA) tracking predicts ONC201 treatment response and progression in diffuse midline glioma

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recommendations! Published in 2022 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noac030

Abstract: Abstract Background Diffuse Midline Glioma (DMG) with the H3K27M mutation is a lethal childhood brain cancer, with patients rarely surviving 2 years from diagnosis. Methods We conducted a multi-site Phase 1 trial of the imipridone… read more here.

Keywords: response; vaf; progression; glioma ... See more keywords
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TERT Promoter Mutation Detection in Cell-Free Tumor-Derived DNA in Patients with IDH Wild-Type Glioblastomas: A Pilot Prospective Study

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recommendations! Published in 2018 at "Clinical Cancer Research"

DOI: 10.1158/1078-0432.ccr-17-3717

Abstract: Purpose: We conducted a pilot study to assess the feasibility and the potential implications of detecting TERT promoter (TERTp)–mutant cell-free tumor-derived DNA (tDNA) in the cerebrospinal fluid (CSF) and plasma of glioblastoma patients. Experimental Design:… read more here.

Keywords: vaf; csf tdna; study; mutation ... See more keywords
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NPM1 Variant Allele Frequency and Outcomes in AML

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recommendations! Published in 2018 at "Blood"

DOI: 10.1182/blood-2018-99-112549

Abstract: Background: Mutations in the NPM1 gene are among the most common genetic alterations in patients with acute myeloid leukemia (AML). NPM1 mutations predominantly occur in patients with normal or intermediate-risk abnormal cytogenetics, and define a… read more here.

Keywords: npm1 vaf; vaf; consultancy; research funding ... See more keywords
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GeTallele: A Method for Analysis of DNA and RNA Allele Frequency Distributions

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recommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"

DOI: 10.3389/fbioe.2020.01021

Abstract: Variant allele frequencies (VAF) are an important measure of genetic variation that can be estimated at single-nucleotide variant (SNV) sites. RNA and DNA VAFs are used as indicators of a wide-range of biological traits, including… read more here.

Keywords: methodology; vaf; dna; dna rna ... See more keywords
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Comparative Transcriptome Analysis Provides Insight into Spatio-Temporal Expression Characteristics and Genetic Regulatory Network in Postnatal Developing Subcutaneous and Visceral Fat of Bama Pig

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recommendations! Published in 2022 at "Frontiers in Genetics"

DOI: 10.3389/fgene.2022.844833

Abstract: The depot differences between Subcutaneous Fat (SAF) and Visceral Fat (VAF) are critical for human well-being and disease processes in regard to energy metabolism and endocrine function. Miniature pigs (Sus scrofa) are ideal biomedical models… read more here.

Keywords: vaf; metabolism; development; expression ... See more keywords

Prediction of herbal medicines based on immune cell infiltration and immune- and ferroptosis-related gene expression levels to treat valvular atrial fibrillation

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recommendations! Published in 2022 at "Frontiers in Genetics"

DOI: 10.3389/fgene.2022.886860

Abstract: Inflammatory immune response is apparently one of the determinants of progressive exacerbation of valvular atrial fibrillation(VAF). Ferroptosis, an iron-dependent modality of regulated cell death, is involved in the immune regulation of cardiovascular disease. However, the… read more here.

Keywords: infiltration; vaf; valvular atrial; ferroptosis related ... See more keywords