Cell Lineage Tracing Identifies Hormone-Regulated and Wnt-Responsive Vaginal Epithelial Stem Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.003
Abstract: The intact vaginal epithelium is essential for women's reproductive health and provides protection against HIV and sexually transmitted infections. How this epithelium maintains itself remains poorly understood. Here, we used single-cell RNA sequencing (RNA-seq) to… read more here.
Keywords: vaginal epithelium; vaginal epithelial; epithelial stem; stem ... See more keywords
Hyperosmolal vaginal lubricants markedly reduce epithelial barrier properties in a three-dimensional vaginal epithelium model
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology Reports"
DOI: 10.1016/j.toxrep.2017.12.011
Abstract: Most of the widely used vaginal lubricants in the U.S. and Europe are strongly hyperosmolal, formulated with high concentrations of glycerol, propylene glycol, polyquaternary compounds or other ingredients that make these lubricants 4 to 30… read more here.
Keywords: three dimensional; vaginal epithelium; vaginal lubricants; model ... See more keywords
Potential of mucoadhesive chitosan glutamate microparticles as microbicide carriers – antiherpes activity and penetration behavior across the human vaginal epithelium
Sign Up to like & getrecommendations! Published in 2021 at "Drug Delivery"
DOI: 10.1080/10717544.2021.1992037
Abstract: Abstract Chitosan glutamate (gCS) spray-dried microparticles appear promising carriers to overcome challenges associated with vaginal microbicide delivery. This study aimed at elucidating the penetration and mucoadhesive behavior of developed gCS multiunit carriers with zidovudine (ZVD)… read more here.
Keywords: vaginal epithelium; human vaginal; penetration; antiherpes activity ... See more keywords
The effect of serotonin reuptake inhibitors on the vaginal epithelium in postmenopausal women
Sign Up to like & getrecommendations! Published in 2019 at "Climacteric"
DOI: 10.1080/13697137.2019.1604655
Abstract: Abstract Purpose: Selective serotonin reuptake inhibitors (SSRIs) and serotonin–norepinephrine reuptake inhibitors (SNRIs) are used as alternative treatments for the vasomotor symptoms of menopause in women who are unwilling or unable to receive hormone therapy. These… read more here.
Keywords: vaginal epithelium; serotonin reuptake; reuptake inhibitors; effect ... See more keywords
Nystatin enhances the immune response against Candida albicans and protects the ultrastructure of the vaginal epithelium in a rat model of vulvovaginal candidiasis
Sign Up to like & getrecommendations! Published in 2018 at "BMC Microbiology"
DOI: 10.1186/s12866-018-1316-3
Abstract: BackgroundVulvovaginal candidiasis (VVC) is a common infectious disease of the lower genital tract. Nystatin, a polyene fungicidal antibiotic, is used as a topical antifungal agent for VVC treatment. The aim of the current study was… read more here.
Keywords: vaginal epithelium; ultrastructure vaginal; response; nystatin ... See more keywords
Neonatal administration of synthetic estrogen, diethylstilbestrol to mice up-regulates inflammatory Cxclchemokines located in the 5qE1 region in the vaginal epithelium
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0280421
Abstract: A synthetic estrogen, diethylstilbestrol (DES), is known to cause adult vaginal carcinoma by neonatal administration of DES to mice. However, the carcinogenic process remains unclear. By Cap Analysis of Gene Expression method, we found that… read more here.
Keywords: synthetic estrogen; vaginal epithelium; neonatal administration; region ... See more keywords
Effects of retinoid-loaded hyaluronic acid nanomicelles on vaginal epithelium in a murine menopause model
Sign Up to like & getrecommendations! Published in 2023 at "Investigative and Clinical Urology"
DOI: 10.4111/icu.20220366
Abstract: Purpose This study aimed to develop hyaluronic acid (HA)-based, retinoic acid (RA)-containing nanomicelles and to investigate the effects of these newly developed nanomicelles on regeneration of the vaginal epithelium and aquaporin 3 (AQP3) expression in… read more here.
Keywords: murine menopause; group; vaginal epithelium; c18 ... See more keywords