Impact of the Dapivirine Vaginal Ring on Sexual Experiences and Intimate Partnerships of Women in an HIV Prevention Clinical Trial: Managing Ring Detection and Hot Sex
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DOI: 10.1007/s10461-017-1977-1
Abstract: Vaginally-inserted HIV prevention methods have been reported to impact the sexual experience for women and their partners, and hence impacts acceptability of and adherence to the method. We analyzed in-depth interviews and focus group discussions… read more here.
Keywords: hiv prevention; vaginal ring; dapivirine vaginal; sex ... See more keywords
Hygiene, Blood Flow, and Vaginal Overload: Why Women Removed an HIV Prevention Vaginal Ring During Menstruation in Malawi, South Africa, Uganda and Zimbabwe
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DOI: 10.1007/s10461-019-02514-8
Abstract: We assessed the interference between vaginal ring use and menses among women who participated in the qualitative component of the MTN-020/ASPIRE vaginal ring trial in Malawi, South Africa, Uganda and Zimbabwe (N = 214). A common reason… read more here.
Keywords: south africa; africa uganda; vaginal ring; blood ... See more keywords
Development and pharmacokinetics of a combination vaginal ring for sustained release of dapivirine and the protein microbicide 5P12-RANTES.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.04.040
Abstract: The past fifteen years have witnessed a resurgence of interest in vaginal ring technologies for drug delivery applications, mostly driven by the impetus for development of vaginally-administered antiretroviral microbicides to help reduce the high acquisition… read more here.
Keywords: 5p12 rantes; vaginal ring; sustained release; ring ... See more keywords
Towards a dapivirine and levonorgestrel multipurpose vaginal ring: Investigations into the reaction between levonorgestrel and addition-cure silicone elastomers.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.118574
Abstract: With a dapivirine-releasing vaginal ring having successfully completed late-stage clinical testing for HIV prevention and currently undergoing regulatory review, there is now growing interest in next-generation multipurpose prevention technologies that seek to combine antiretroviral and… read more here.
Keywords: silicone; addition; dapivirine levonorgestrel; vaginal ring ... See more keywords
Influence of dapivirine vaginal ring use on cervicovaginal immunity and functional microbiome in adolescent girls.
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DOI: 10.1097/qad.0000000000002751
Abstract: OBJECTIVE The antiretroviral-based dapivirine vaginal ring reduced HIV risk among women in Phase III clinical trials. However, limited data exists on the impact of dapivirine on the vaginal microenvironment in adolescents. DESIGN A comprehensive metaproteomics… read more here.
Keywords: ring use; vaginal ring; dapivirine vaginal; influence dapivirine ... See more keywords
Patterns of Adherence to a Dapivirine Vaginal Ring for HIV-1 Prevention Among South African Women in a Phase III Randomized Controlled Trial.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of acquired immune deficiency syndromes"
DOI: 10.1097/qai.0000000000002990
Abstract: BACKGROUND Persistent use of HIV prevention methods can be a challenge, particularly for some younger women. The long-acting, discreet, woman-centric dapivirine vaginal ring offers promise as a prevention method with less user burden, which could… read more here.
Keywords: prevention; vaginal ring; dapivirine vaginal; adherence ... See more keywords
Pharmacokinetics and pharmacodynamics of three dosages of oestriol after continuous vaginal ring administration for 21 days in healthy, postmenopausal women
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DOI: 10.1111/bcp.13822
Abstract: Evaluation of the oestriol pharmacokinetics, pharmacodynamics and safety in healthy, postmenopausal women under treatment with a vaginal ring with continuous delivery rates of 0.125 (Test 1), 0.250 (Test 2) or 0.500 mg day–1 (Test 3)… read more here.
Keywords: pharmacodynamics three; three dosages; vaginal ring; pharmacokinetics pharmacodynamics ... See more keywords
O05.3 The combined contraceptive vaginal ring increases Th17-related cytokines in the genital tract: a randomized crossover trial
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DOI: 10.1136/sextrans-2019-sti.130
Abstract: Background Progestin only-injections (NET-EN and DMPA) have been reported to increase HIV target cells in the female genital tract (FGT), which are target cells for HIV infection. Recently, CD4 Th17 cells have been identified to… read more here.
Keywords: related cytokines; combined contraceptive; vaginal ring; genital tract ... See more keywords
Acceptability of an extended duration vaginal ring for HIV prevention and interest in a multi-purpose ring
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DOI: 10.1371/journal.pone.0263664
Abstract: Given challenges with adherence to existing HIV prevention products, the development of an extended duration vaginal ring could improve adherence while reducing patient and provider burden. Additionally, women have other interlinked sexual health concerns such… read more here.
Keywords: extended duration; vaginal ring; duration; hiv prevention ... See more keywords
Multicenter, international observational study on quality of life and acceptability of a vaginal contraceptive ring containing etonogestrel/ethinylestradiol 11.00/3.474 mg over six months of use.
Sign Up to like & getrecommendations! Published in 2022 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202210_29911
Abstract: OBJECTIVE The current post-market study aimed at analyzing women's menstrual bleeding intensity, vaginal infections, and quality of life parameters using the contraceptive vaginal ring Ornibel®. PATIENTS AND METHODS In Germany and Spain, a multicenter study… read more here.
Keywords: six months; ring; vaginal ring; quality life ... See more keywords
Vaginal Microbiota and Mucosal Pharmacokinetics of Tenofovir in Healthy Women Using a 90-Day Tenofovir/Levonorgestrel Vaginal Ring
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DOI: 10.3389/fcimb.2022.799501
Abstract: Background A relationship between the vaginal microbiota and tenofovir (TFV) concentrations and activity after topical administration has been previously reported. Objective CONRAD A15-138 was a randomized, placebo-controlled Phase I study aimed at characterizing the safety,… read more here.
Keywords: ivr; microbiota; tfv; vaginal microbiota ... See more keywords