ACTR-06. CLINICAL TRIAL OF VAL-083 IN NEWLY DIAGNOSED MGMT-UNMETHYLATED GBM: HALF-WAY REPORT
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.050
Abstract: Approximately 60% of glioblastoma multiforme (GBM) patients possess an unmethylated methylguanine DNA-methyltransferase (MGMT gene, which confers a limited response to standard of care treatment with temozolomide (TMZ) resulting in a lower survival. VAL-083 is a… read more here.
Keywords: newly diagnosed; val; mgmt unmethylated; val 083 ... See more keywords
Abstract 1429: DNA damage response to dianhydrogalactitol (VAL-083) in p53-deficient non-small cell lung cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-1429
Abstract: Non-small cell lung cancer (NSCLC) treatment usually involves surgery and chemotherapy with tyrosine kinase inhibitors (TKI) in patients with EGFR mutations (10-15% in Western population, 40% in Asian populations) or with platinum-based regimens. Response to… read more here.
Keywords: dna damage; val 083; cancer; p53 ... See more keywords
Abstract CT272: Phase 2 study of dianhydrogalactitol (VAL-083) in patients with MGMT-unmethylated, bevacizumab-naïve glioblastoma in the recurrent or adjuvant setting
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DOI: 10.1158/1538-7445.am2020-ct272
Abstract: Glioblastoma (GBM) is the most common and aggressive primary brain cancer. Current standard-of-care for glioblastoma (GBM) includes surgery followed by concurrent therapy with radiation and temozolomide (TMZ) followed by adjuvant TMZ (days 1-5 every 28… read more here.
Keywords: glioblastoma; gbm; mgmt unmethylated; group ... See more keywords
Abstract LB126: RELA fusion-positive ependymoma and diffuse midline glioma treated with VAL-083 under expanded access - case reports
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DOI: 10.1158/1538-7445.am2023-lb126
Abstract: Ependymoma can occur anywhere in the central nervous system (CNS), but often occurs near the ventricle of the brain and central canal of the spinal cord. Ependymoma accounts for 5.7% of all childhood and 1.9%… read more here.
Keywords: ependymoma; positive ependymoma; rela fusion; fusion positive ... See more keywords
Abstract B15: Dissecting the molecular mechanism of dianhydrogalactitol (VAL-083) activity in cancer treatment
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DOI: 10.1158/1557-3125.dnarepair16-b15
Abstract: Introduction: Dianhydrogalactitol (VAL-083) is a bi-functional alkylating agent causing N 7 -guanine-methylation and inter-strand DNA crosslinks. In China, VAL-083 is approved to use in the chemotherapeutic treatment of lung cancer and chronic myelogenous leukemia. In… read more here.
Keywords: dna; treatment; cancer cells; cancer ... See more keywords
Abstract A01: Distinct mechanism of action of DNA-damaging agent dianhydrogalactitol (VAL-083) suggests combination therapy with PARP inhibitors
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DOI: 10.1158/1557-3265.ovca17-a01
Abstract: DNA damage response (DDR) is a network of intracellular pathways designed to minimize the impact of DNA damage. Multiple DNA repair pathways are known, including mismatch repair (MMR), O6-methylguanine DNA methyltransferase (MGMT), non-homologous end joining… read more here.
Keywords: val 083; p53; ovarian cancer; dna ... See more keywords
Clinical trials of VAL-083 in patients with chemo-resistant glioblastoma.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.tps2082
Abstract: TPS2082Background: Glioblastoma (GBM) is the most common and aggressive primary brain cancer. Current standard of care includes surgery, radiation and treatment with temozolomide (TMZ), however nearly all tumors recur and the prognosis for recurrent GBM… read more here.
Keywords: glioblastoma; gbm; clinical trials; 083 patients ... See more keywords