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   Articles with "val158met polymorphism" as a keyword



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Impact of the catechol-O-methyltransferase Val158Met polymorphism on the pharmacokinetics of l-dopa and its metabolite 3-O-methyldopa in combination with entacapone

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recommendations! Published in 2020 at "Journal of Neural Transmission"

DOI: 10.1007/s00702-020-02267-y

Abstract: In the pharmacotherapy of patients with Parkinson’s disease (PD), entacapone reduces the peripheral metabolism of l-dopa to 3-O-methyldopa (3-OMD), thereby prolonging the half-life (t1/2) of l-dopa and increasing the area under the concentration curve (AUC).… read more here.

Keywords: catechol methyltransferase; val158met polymorphism; dopa; entacapone ... See more keywords
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Catechol-O-methyltransferase gene Val158Met polymorphism and obsessive compulsive disorder susceptibility: a meta-analysis

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recommendations! Published in 2019 at "Metabolic Brain Disease"

DOI: 10.1007/s11011-019-00495-0

Abstract: Obsessive–compulsive disorder (OCD) is a common psychiatric disorder that affects approximately 1–3% of the general population. It is characterized by disabling obsessions (intrusive unwanted thoughts) and/or compulsions (ritualized repetitive behaviors). Catechol-O-methyltransferase (COMT) enzyme has an… read more here.

Keywords: analysis; comt; val158met polymorphism; meta analysis ... See more keywords
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Appetite effects of prefrontal stimulation depend on COMT Val158Met polymorphism: A randomized clinical trial

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recommendations! Published in 2019 at "Appetite"

DOI: 10.1016/j.appet.2019.05.015

Abstract: The regulation of appetite is supported by dopamine-modulated brain circuits. Recent studies have shown that transcranial direct current stimulation (tDCS) aimed at increasing the excitability of the dorsolateral prefrontal cortex can reduce appetite, but the… read more here.

Keywords: stimulation; comt val158met; val158met polymorphism; tdcs ... See more keywords
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Motor learning and COMT Val158met polymorphism: Analyses of oculomotor behavior and corticocortical communication

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recommendations! Published in 2020 at "Neurobiology of Learning and Memory"

DOI: 10.1016/j.nlm.2020.107157

Abstract: Differences in motor learning can be partially explained by differences in genotype. The catechol-O-methyltransferase (COMT) Val158Met polymorphism regulates the dopamine (DA) availability in the prefrontal cortex modulating motor learning and performance. Given the differences in… read more here.

Keywords: comt val158met; val158met polymorphism; motor learning; motor ... See more keywords
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Association between COMT Val158Met polymorphism and competition results of competitive swimmers

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recommendations! Published in 2018 at "Journal of Sports Sciences"

DOI: 10.1080/02640414.2017.1309058

Abstract: ABSTRACT Recent studies have shown the contribution of genetic determinants to athletes’ physical ability. However, despite the fact that cognitive abilities like self-control and stress-tolerance influence athletes’ competitive performance, few studies to date have investigated… read more here.

Keywords: competitive performance; association comt; competitive swimmers; val158met polymorphism ... See more keywords

Interrogating the Relationship Between Schizotypy, the Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism, and Neuronal Oscillatory Activity.

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recommendations! Published in 2018 at "Cerebral cortex"

DOI: 10.1093/cercor/bhy171

Abstract: The COMT Val158Met polymorphism affects the availability of synaptic dopamine in the prefrontal cortex and has been widely studied as a genetic risk factor for psychosis. Schizotypy is associated with an increased risk of psychosis,… read more here.

Keywords: schizotypy; comt val158met; val158met polymorphism; comt ... See more keywords
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Association of Val158Met polymorphism in COMT gene with attention-deficit hyperactive disorder

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recommendations! Published in 2020 at "Medicine"

DOI: 10.1097/md.0000000000023400

Abstract: Abstract Background: The results of published articles on the relationship between the Val158Met polymorphism in the (Catechol-O-methyltransferase) COMT gene and the susceptibility of attention-deficit hyperactive disorder (ADHD) are controversial. We conducted an updated meta-analysis of… read more here.

Keywords: val158met polymorphism; gene; association; comt gene ... See more keywords
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COMT Val158Met Polymorphism Exerts Sex-Dependent Effects on fMRI Measures of Brain Function

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recommendations! Published in 2017 at "Frontiers in Human Neuroscience"

DOI: 10.3389/fnhum.2017.00578

Abstract: Evidence suggests that dopamine levels in the prefrontal cortex (PFC) modulate executive functions. A key regulator of PFC dopamine is catechol-O-methyltransferase (COMT). The activity level of the COMT enzyme are influenced by sex and the… read more here.

Keywords: comt genotype; val158met polymorphism; comt; sex ... See more keywords