Identification and Validation of Driver Kinases from Next-Generation Sequencing Data.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7154-1_12
Abstract: It is well appreciated that activating mutations in kinase genes result in kinome reprogramming that leads to altered downstream signaling networks that drive tumor progression. Indeed small-molecule inhibition of activated kinases has heralded the wave… read more here.
Keywords: validation driver; next generation; generation sequencing; identification validation ... See more keywords