METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01601
Abstract: RNA methylation is a critical mechanism for regulating the transcription and translation of specific sequences or for eliminating unnecessary sequences during RNA maturation. METTL3, an RNA methyltransferase that catalyzes the transfer of a methyl group… read more here.
Keywords: medicinal chemistry; mettl3 target; chemistry; validation first ... See more keywords
Design and Validation of the First Family of Photo-Activatable Ligands for Melatonin Receptors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1101/2022.05.05.490738
Abstract: Melatonin is a neurohormone released in a circadian manner with peak levels during the night. In mammals, melatonin mediates its effects mainly through G protein-coupled MT1 and MT2 receptors. Drugs acting on melatonin receptors are… read more here.
Keywords: family; design validation; mcs 0382; validation first ... See more keywords
Intercomparison and validation of first GLORIA-B measurements of stratospheric and upper tropospheric long-lived tracers and photochemically active species
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DOI: 10.5194/amt-18-5873-2025
Abstract: Abstract. Accurate observations of the vertical distribution and variability of atmospheric trace gases are essential for understanding chemical processes, validating atmospheric models, and monitoring the impact of anthropogenic emissions on climate and ozone. The Gimballed… read more here.
Keywords: chemistry; validation first; validation; active species ... See more keywords