Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease.
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DOI: 10.1016/j.stem.2017.01.010
Abstract: Genome-wide association studies (GWAS) have highlighted a large number of genetic variants with potential disease association, but functional analysis remains a challenge. Here we describe an approach to functionally validate identified variants through differentiation of induced… read more here.
Keywords: functional validation; disease; validation gwas; pluripotent stem ... See more keywords