Validation of Top-Down Proteomics Data by Bottom-Up-Based N-Terminomics Reveals Pitfalls in Top-Down-Based Terminomics Workflows.
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DOI: 10.1021/acs.jproteome.2c00277
Abstract: Bottom-up proteomics (BUP)-based N-terminomics techniques have become standard to identify protein N-termini. While these methods rely on the identification of N-terminal peptides only, top-down proteomics (TDP) comes with the promise to provide additional information about… read more here.
Keywords: top proteomics; proteomics data; data bottom; based terminomics ... See more keywords